Ceftaroline Cerebrospinal Fluid Penetration in the Treatment of a Ventriculopleural Shunt Infection: A Case Report.
CSF penetration
MRSA
case report
ceftaroline CSF concentrations
ceftaroline fosamil
pediatric
pharmacodynamics
pharmacokinetic
Journal
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
ISSN: 1551-6776
Titre abrégé: J Pediatr Pharmacol Ther
Pays: United States
ID NLM: 101089851
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
29
5
2020
pubmed:
29
5
2020
medline:
29
5
2020
Statut:
ppublish
Résumé
Pharmacokinetic data regarding ceftaroline fosamil (CPT) penetration into cerebrospinal fluid (CSF) are limited to a rabbit model (15% inflamed) and adult case reports. We describe serum and CSF CPT concentrations in a 21-year-old, 34.8 kg female, medically complex patient presented with a 4-day history of fevers (Tmax 39.2°C), tachypnea, tachycardia, fatigue, and a 1-week history of pus and blood draining from the ventriculopleural (VPL) shunt. A head CT and an ultrasound of the neck revealed septated complex fluid collection surrounding the shunt. Therapy was initiated with vancomycin and ceftriaxone. Blood and CSF cultures from hospital day (HD) 1 were positive for methicillin-resistant
Identifiants
pubmed: 32461749
doi: 10.5863/1551-6776-25.4.336
pmc: PMC7243901
doi:
Types de publication
Case Reports
Langues
eng
Pagination
336-339Informations de copyright
Copyright Pediatric Pharmacy Association. All rights reserved. For permissions, email: mhelms@pediatricpharmacy.org 2020.
Déclaration de conflit d'intérêts
Disclosure Jeffrey J. Cies PharmD, MPH is a consultant for Atlantic Diagnostic Laboratories and has received grants and/or honoraria from Allergan, Merck, Thermo Fisher Scientific, and Melinta. The other authors declare no conflicts or financial interest in any product or service mentioned in the manuscript, including grants, equipment, medications, employment, gifts, and honoraria. There was no grant or funding to support this work.
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