Free fatty acids receptors 2 and 3 control cell proliferation by regulating cellular glucose uptake.
Cell proliferation
Colorectal cancer
Free fatty acids receptor 2
Free fatty acids receptor 3
Glucose transporter 1
Glucose uptake
Journal
World journal of gastrointestinal oncology
ISSN: 1948-5204
Titre abrégé: World J Gastrointest Oncol
Pays: China
ID NLM: 101532470
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
17
12
2019
revised:
18
03
2020
accepted:
28
03
2020
entrez:
29
5
2020
pubmed:
29
5
2020
medline:
29
5
2020
Statut:
ppublish
Résumé
Colorectal cancer (CRC) is a worldwide problem, which has been associated with changes in diet and lifestyle pattern. As a result of colonic fermentation of dietary fibres, short chain free fatty acids are generated which activate free fatty acid receptors (FFAR) 2 and 3. To understand the role of short chain FFARs in CRC. Transcriptome analysis console software was used to analyse microarray data from CRC patients and cell lines. We employed short-hairpin RNA mediated down regulation of Microarray data analysis of CRC patient samples showed a significant down regulation of Our results suggest role of
Sections du résumé
BACKGROUND
BACKGROUND
Colorectal cancer (CRC) is a worldwide problem, which has been associated with changes in diet and lifestyle pattern. As a result of colonic fermentation of dietary fibres, short chain free fatty acids are generated which activate free fatty acid receptors (FFAR) 2 and 3.
AIM
OBJECTIVE
To understand the role of short chain FFARs in CRC.
METHODS
METHODS
Transcriptome analysis console software was used to analyse microarray data from CRC patients and cell lines. We employed short-hairpin RNA mediated down regulation of
RESULTS
RESULTS
Microarray data analysis of CRC patient samples showed a significant down regulation of
CONCLUSION
CONCLUSIONS
Our results suggest role of
Identifiants
pubmed: 32461783
doi: 10.4251/wjgo.v12.i5.514
pmc: PMC7235185
doi:
Types de publication
Journal Article
Langues
eng
Pagination
514-525Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
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