Current challenges and possible future developments in personalized psychiatry with an emphasis on psychotic disorders.
Bioinformatics
Biomarker
Evidence-based medicine
Genetics
Human brain
Machine learning
Mathematical biosciences
Molecular biology
Neuroscience
Pathophysiology
Pharmaceutical science
Pharmacotherapy
Psychiatry
RDoC
Schizophrenia
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
13
07
2019
revised:
31
10
2019
accepted:
12
05
2020
entrez:
29
5
2020
pubmed:
29
5
2020
medline:
29
5
2020
Statut:
epublish
Résumé
A personalized medicine approach seems to be particularly applicable to psychiatry. Indeed, considering mental illness as deregulation, unique to each patient, of molecular pathways, governing the development and functioning of the brain, seems to be the most justified way to understand and treat disorders of this medical category. In order to extract correct information about the implicated molecular pathways, data can be drawn from sampling phenotypic and genetic biomarkers and then analyzed by a machine learning algorithm. This review describes current difficulties in the field of personalized psychiatry and gives several examples of possibly actionable biomarkers of psychotic and other psychiatric disorders, including several examples of genetic studies relevant to personalized psychiatry. Most of these biomarkers are not yet ready to be introduced in clinical practice. In a next step, a perspective on the path personalized psychiatry may take in the future is given, paying particular attention to machine learning algorithms that can be used with the goal of handling multidimensional datasets.
Identifiants
pubmed: 32462093
doi: 10.1016/j.heliyon.2020.e03990
pii: S2405-8440(20)30835-5
pii: e03990
pmc: PMC7240336
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e03990Informations de copyright
© 2020 The Author(s).
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