Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents.
A549 Cells
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
Coordination Complexes
/ chemical synthesis
Crystallography, X-Ray
DNA Topoisomerases, Type I
/ metabolism
Density Functional Theory
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Gold
/ chemistry
Humans
Models, Molecular
Molecular Structure
Phosphines
/ chemistry
Structure-Activity Relationship
Sulfides
/ chemistry
Topoisomerase I Inhibitors
/ chemical synthesis
Journal
Dalton transactions (Cambridge, England : 2003)
ISSN: 1477-9234
Titre abrégé: Dalton Trans
Pays: England
ID NLM: 101176026
Informations de publication
Date de publication:
21 Jun 2020
21 Jun 2020
Historique:
pubmed:
29
5
2020
medline:
2
2
2021
entrez:
29
5
2020
Statut:
ppublish
Résumé
This work describes the synthesis of the gold(i) complexes of phosphine sulphides. The formation of these new derivatives has been confirmed by X-ray crystallography. The coordination of gold(i) with the sulphur atom of the phosphine sulphides favors the inhibition of topoisomerase I as well as a high cytotoxicity of the gold(i)-complexed compounds against the cancer line A549 with IC
Substances chimiques
Antineoplastic Agents
0
Coordination Complexes
0
Phosphines
0
Sulfides
0
Topoisomerase I Inhibitors
0
Gold
7440-57-5
DNA Topoisomerases, Type I
EC 5.99.1.2
TOP1 protein, human
EC 5.99.1.2
phosphine
FW6947296I
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM