Circular RNA_0001742 has potential to predict advanced tumor stage and poor survival profiles in tongue squamous cell carcinoma management.
circular RNA_0001742
overall survival
reverse transcription-quantitative polymerase chain reaction
tongue squamous cell carcinoma
tumor stage
Journal
Journal of clinical laboratory analysis
ISSN: 1098-2825
Titre abrégé: J Clin Lab Anal
Pays: United States
ID NLM: 8801384
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
24
02
2020
revised:
16
03
2020
accepted:
18
03
2020
pubmed:
29
5
2020
medline:
22
6
2021
entrez:
29
5
2020
Statut:
ppublish
Résumé
Circular RNA_0001742 (circ_0001742) has been reported to be upregulated in tongue squamous cell carcinoma (TSCC) tissues/cells and regulate TSCC cell proliferation, migration, and invasion. This study aimed to further investigate the clinical significance of circ_0001742 in TSCC management. Totally, 146 TSCC patients underwent surgical treatment were reviewed. Their fresh-frozen tumor tissue and adjacent tissue were acquired for detecting circ_0001742 expression via reverse transcription-quantitative polymerase chain reaction. According to circ_0001742 expression in tumor tissue, all patients were classified as tumor circ_0001742 low (0%-50% percentile) and high (50%-100% percentile) patients, the latter were further divided into the tumor circ_0001742 high+ (50%-75% percentile), high++ (75%-90% percentile), and high+++ (90%-100% percentile) patients, respectively. Circ_0001742 expression was increased in TSCC tumor tissue compared with adjacent tissue, and it presented good value in discriminating tumor tissue from adjacent tissue (area under the curve (AUC): 0.870, 95% CI: 0.831-0.910). Tumor high circ_0001742 expression was associated with higher T stage, N stage, and TNM stage, but not age, gender, or pathological grade. Furthermore, OS was reduced in tumor circ_0001742 high patients compared with tumor circ_0001742 low patients; moreover, OS was the shortest in tumor circ_0001742 high+++ patients, followed by tumor circ_0001742 high++ patients and tumor circ_0001742 high+ patients, and the longest in tumor circ_0001742 low patients. In addition, multivariate Cox's regression analysis revealed that higher tumor circ_0001742 expression was an independent predictive factor for decreased OS. Circ_0001742 serves as a potential biomarker for advanced tumor stage and poor survival in TSCC patients.
Sections du résumé
BACKGROUND
BACKGROUND
Circular RNA_0001742 (circ_0001742) has been reported to be upregulated in tongue squamous cell carcinoma (TSCC) tissues/cells and regulate TSCC cell proliferation, migration, and invasion. This study aimed to further investigate the clinical significance of circ_0001742 in TSCC management.
METHODS
METHODS
Totally, 146 TSCC patients underwent surgical treatment were reviewed. Their fresh-frozen tumor tissue and adjacent tissue were acquired for detecting circ_0001742 expression via reverse transcription-quantitative polymerase chain reaction. According to circ_0001742 expression in tumor tissue, all patients were classified as tumor circ_0001742 low (0%-50% percentile) and high (50%-100% percentile) patients, the latter were further divided into the tumor circ_0001742 high+ (50%-75% percentile), high++ (75%-90% percentile), and high+++ (90%-100% percentile) patients, respectively.
RESULTS
RESULTS
Circ_0001742 expression was increased in TSCC tumor tissue compared with adjacent tissue, and it presented good value in discriminating tumor tissue from adjacent tissue (area under the curve (AUC): 0.870, 95% CI: 0.831-0.910). Tumor high circ_0001742 expression was associated with higher T stage, N stage, and TNM stage, but not age, gender, or pathological grade. Furthermore, OS was reduced in tumor circ_0001742 high patients compared with tumor circ_0001742 low patients; moreover, OS was the shortest in tumor circ_0001742 high+++ patients, followed by tumor circ_0001742 high++ patients and tumor circ_0001742 high+ patients, and the longest in tumor circ_0001742 low patients. In addition, multivariate Cox's regression analysis revealed that higher tumor circ_0001742 expression was an independent predictive factor for decreased OS.
CONCLUSION
CONCLUSIONS
Circ_0001742 serves as a potential biomarker for advanced tumor stage and poor survival in TSCC patients.
Identifiants
pubmed: 32463532
doi: 10.1002/jcla.23330
pmc: PMC7439411
doi:
Substances chimiques
RNA, Circular
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23330Subventions
Organisme : Youth Science and technology project of Health and Family Planning Commission of Hebei Province
ID : 20191158
Informations de copyright
© 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.
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