Nanoparticle-hydrogel superstructures for biomedical applications.

Detoxification Drug delivery Hydrogel hybrid Immune modulation Nanomedicine Nanoparticle Tissue engineering

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
10 08 2020
Historique:
received: 25 04 2020
revised: 23 05 2020
accepted: 25 05 2020
pubmed: 29 5 2020
medline: 22 6 2021
entrez: 29 5 2020
Statut: ppublish

Résumé

The incorporation of nanoparticles into hydrogels yields novel superstructures that have become increasingly popular in biomedical research. Each component of these nanoparticle-hydrogel superstructures can be easily modified, resulting in platforms that are highly tunable and inherently multifunctional. The advantages of the nanoparticle and hydrogel constituents can be synergistically combined, enabling these superstructures to excel in scenarios where employing each component separately may have suboptimal outcomes. In this review, the synthesis and fabrication of different nanoparticle-hydrogel superstructures are discussed, followed by an overview of their use in a range of applications, including drug delivery, detoxification, immune modulation, and tissue engineering. Overall, these platforms hold significant clinical potential, and it is envisioned that future development along these lines will lead to unique solutions for addressing areas of pressing medical need.

Identifiants

pubmed: 32464152
pii: S0168-3659(20)30318-7
doi: 10.1016/j.jconrel.2020.05.041
pmc: PMC7429280
mid: NIHMS1601741
pii:
doi:

Substances chimiques

Hydrogels 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

505-521

Subventions

Organisme : NCI NIH HHS
ID : R01 CA200574
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA153915
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

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Auteurs

Yao Jiang (Y)

Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

Nishta Krishnan (N)

Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

Jiyoung Heo (J)

Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

Ronnie H Fang (RH)

Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: rhfang@ucsd.edu.

Liangfang Zhang (L)

Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: zhang@ucsd.edu.

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Classifications MeSH