Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.

Animals Capillaries Endothelial Progenitor Cells Kidney Kidney Medulla Mice Neoplasms Receptors, G-Protein-Coupled / genetics
Acute kidney injury Ischemia Stem cells Vasa recta

Journal

Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957

Informations de publication

Date de publication:
07 2020
Historique:
received: 19 11 2019
revised: 13 02 2020
accepted: 12 05 2020
pubmed: 29 5 2020
medline: 22 6 2021
entrez: 29 5 2020
Statut: ppublish

Résumé

The Wnt pathway co-receptor, Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5), labels tumor-prone stem cell populations in certain types of tissue. In this study, we show that ARID1A and PIK3CA mutations in LGR5

Identifiants

DOI: 10.1016/j.scr.2020.101849 PMID: 32464345
pubmed: 32464345
pii: S1873-5061(20)30150-1
doi: 10.1016/j.scr.2020.101849
pii:
doi:

Substances chimiques

Lgr5 protein, mouse 0
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101849

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Mike R Wilson (MR)

Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA.

Jeanne Holladay (J)

Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA.

Rachael Sheridan (R)

Flow Cytometry Core, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Galen Hostetter (G)

Pathology and Biorepository Core, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Bree Berghuis (B)

Pathology and Biorepository Core, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Carrie Graveel (C)

Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Curt Essenburg (C)

Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Anderson Peck (A)

Small Animal Imaging Facility, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Thai H Ho (TH)

Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.

Melissa Stanton (M)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ 85259, USA.

Ronald L Chandler (RL)

Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA; Department of Women's Health, Spectrum Health System, Grand Rapids, MI 49341, USA. Electronic address: rlc@msu.edu.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Lgr5-positive endothelial progenitor cells...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Microvaisseaux › Vaisseaux capillaires › Lgr5-positive endothelial progenitor cells...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Progéniteurs endothéliaux › Lgr5-positive endothelial progenitor cells...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Lgr5-positive endothelial progenitor cells...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Médulla rénale › Lgr5-positive endothelial progenitor cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lgr5-positive endothelial progenitor cells...
questionsmedicales.fr › Tumeurs › Lgr5-positive endothelial progenitor cells...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Lgr5-positive endothelial progenitor cells...