The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders.
Alzheimer's disease
Autism spectrum disorder
Brain disorders
Neurodegeneration
Neurodevelopmental disorders
Nitric oxide
Psychiatry
S-nitrosylation
SHANK3
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
13
02
2020
revised:
04
05
2020
accepted:
05
05
2020
pubmed:
29
5
2020
medline:
22
6
2021
entrez:
29
5
2020
Statut:
ppublish
Résumé
Nitric oxide (NO) is a multifunctional signalling molecule and a neurotransmitter that plays an important role in physiological and pathophysiological processes. In physiological conditions, NO regulates cell survival, differentiation and proliferation of neurons. It also regulates synaptic activity, plasticity and vesicle trafficking. NO affects cellular signalling through protein S-nitrosylation, the NO-mediated posttranslational modification of cysteine thiols (SNO). SNO can affect protein activity, protein-protein interaction and protein localization. Numerous studies have shown that excessive NO and SNO can lead to nitrosative stress in the nervous system, contributing to neuropathology. In this review, we summarize the role of NO and SNO in the progression of neurodevelopmental, psychiatric and neurodegenerative disorders, with special attention to autism spectrum disorder (ASD). We provide mechanistic insights into the contribution of NO in diverse brain disorders. Finally, we suggest that pharmacological agents that can inhibit or augment the production of NO as well as new approaches to modulate the formation of SNO-proteins can serve as a promising approach for the treatment of diverse brain disorders.
Identifiants
pubmed: 32464501
pii: S2213-2317(20)30252-4
doi: 10.1016/j.redox.2020.101567
pmc: PMC7256645
pii:
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101567Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no competing interests to declare.
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