Hypoxia-induced pulmonary hypertension-Utilizing experiments of nature.
genetics
high-altitude
hypoxia-inducible factor
hypoxiainducible factor prolyl hydroxylase 2
oxygen sensing
pulmonary vasoconstriction
vascular remodelling
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
21
02
2020
revised:
26
04
2020
accepted:
30
04
2020
pubmed:
29
5
2020
medline:
22
6
2021
entrez:
29
5
2020
Statut:
ppublish
Résumé
An increase in pulmonary artery pressure is a common observation in adult mammals exposed to global alveolar hypoxia. It is considered a maladaptive response that places an increased workload on the right ventricle. The mechanisms initiating and maintaining the elevated pressure are of considerable interest in understanding pulmonary vascular homeostasis. There is an expectation that identifying the key molecules in the integrated vascular response to hypoxia will inform potential drug targets. One strategy is to take advantage of experiments of nature, specifically, to understand the genetic basis for the inter-individual variation in the pulmonary vascular response to acute and chronic hypoxia. To date, detailed phenotyping of highlanders has focused on haematocrit and oxygen saturation rather than cardiovascular phenotypes. This review explores what we can learn from those studies with respect to the pulmonary circulation. LINKED ARTICLES: This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.1/issuetoc.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
121-131Subventions
Organisme : British Heart Foundation
ID : PG/12/61/29818
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/18/2/33446
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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