Nutraceutical Effects of Lycopene in Experimental Varicocele: An "In Vivo" Model to Study Male Infertility.
Animals
Antioxidants
/ pharmacology
Apoptosis
/ drug effects
Carotenoids
/ pharmacology
Dietary Supplements
In Situ Nick-End Labeling
Infertility, Male
/ drug therapy
Lycopene
/ pharmacology
Male
Malondialdehyde
/ blood
Oxidative Stress
/ drug effects
Proto-Oncogene Proteins c-bcl-2
/ genetics
Rats
Rats, Sprague-Dawley
Testis
/ drug effects
Testosterone
/ blood
Varicocele
/ drug therapy
bcl-2-Associated X Protein
/ genetics
apoptosis
carotenoids
diet
lycopene
nutraceuticals
oxidative stress
rat
testis
varicocele
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
25 May 2020
25 May 2020
Historique:
received:
24
03
2020
revised:
09
05
2020
accepted:
22
05
2020
entrez:
30
5
2020
pubmed:
30
5
2020
medline:
23
2
2021
Statut:
epublish
Résumé
Varicocele is one of the main causes of infertility in men. Oxidative stress and consequently apoptosis activation contribute to varicocele pathogenesis, worsening its prognosis. Natural products, such as lycopene, showed antioxidant and anti-inflammatory effects in several experimental models, also in testes. In this study we investigated lycopene effects in an experimental model of varicocele. Male rats (
Identifiants
pubmed: 32466161
pii: nu12051536
doi: 10.3390/nu12051536
pmc: PMC7284888
pii:
doi:
Substances chimiques
Antioxidants
0
Bax protein, rat
0
Bcl2 protein, rat
0
Proto-Oncogene Proteins c-bcl-2
0
bcl-2-Associated X Protein
0
Carotenoids
36-88-4
Testosterone
3XMK78S47O
Malondialdehyde
4Y8F71G49Q
Lycopene
SB0N2N0WV6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no actual or potential competing financial interests.
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