Genomic and Transcriptomic Characteristics According to Size of Papillary Thyroid Microcarcinoma.
genome
massively parallel sequencing
molecular characteristics
papillary thyroid microcarcinoma
transcriptome
tumor size
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 May 2020
25 May 2020
Historique:
received:
04
05
2020
revised:
20
05
2020
accepted:
22
05
2020
entrez:
30
5
2020
pubmed:
30
5
2020
medline:
30
5
2020
Statut:
epublish
Résumé
It is controversial as to whether papillary thyroid microcarcinoma (PTMC) has some genomic and transcriptomic characteristics that differentiate between an early-stage lesion that would eventually evolve into the larger papillary thyroid cancer (PTC), and an occult indolent cancer in itself. To investigate this, we comprehensively elucidated the genomic and transcriptomic landscapes of PTMCs of different sizes, using a large-scaled database. This study included 3435 PTCs, 1985 of which were PTMCs. We performed targeted next-generation sequencing for 221 PTCs and integrated these data with the data including The Cancer Genome Atlas (TCGA) project. The frequency of v-raf murine sarcoma viral oncogene homolog B (
Identifiants
pubmed: 32466217
pii: cancers12051345
doi: 10.3390/cancers12051345
pmc: PMC7281223
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Ministry of Science and ICT, South Korea
ID : NRF-2019R1A2C2084332
Organisme : SK Telecom
ID : 2012-2013
Organisme : Ministry of Science and ICT, South Korea
ID : NRF-2020R1C1C1003924
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