DFIQ, a Novel Quinoline Derivative, Shows Anticancer Potential by Inducing Apoptosis and Autophagy in NSCLC Cell and In Vivo Zebrafish Xenograft Models.
DFIQ
ROS
apoptosis
lysosome accumulation
non-small-cell lung cancer (NSCLC)
quinoline derivative
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 May 2020
25 May 2020
Historique:
received:
06
02
2020
revised:
18
03
2020
accepted:
20
03
2020
entrez:
30
5
2020
pubmed:
30
5
2020
medline:
30
5
2020
Statut:
epublish
Résumé
Lung cancer is one of the deadliest cancers worldwide due to chemoresistance in patients with late-stage disease. Quinoline derivatives show biological activity against HIV, malaria, bacteriuria, and cancer. DFIQ is a novel synthetic quinoline derivative that induces cell death in both in vitro and in vivo zebrafish xenograft models. DFIQ induced cell death, including apoptosis, and the IC
Identifiants
pubmed: 32466291
pii: cancers12051348
doi: 10.3390/cancers12051348
pmc: PMC7281296
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST107-2320-B-037-023
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST108-2314-B-037-051
Organisme : NSYSU-KMU
ID : NSYSU-KMU108-P021
Organisme : Kansai Medical University
ID : KMU-TC108A04
Organisme : Kaohsiung Medical University
ID : KMU-TC108A03-2
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