Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis.
8-OHdG
Biomarker
Meta-analysis
Oxidative stress
Systematic review
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 May 2020
26 May 2020
Historique:
received:
30
04
2020
revised:
21
05
2020
accepted:
22
05
2020
entrez:
30
5
2020
pubmed:
30
5
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Oxidative stress reflects a disturbance in the balance between the production and accumulation of reactive oxygen species (ROS). ROS are scavenged by the antioxidant system, but when in excess concentration, they can oxidize proteins, lipids, and DNA. DNA damage is usually repaired, and the oxidized products are excreted in urine. 8-hydroxy-2-deoxyguanosine is considered a biomarker for oxidative damage of DNA. It is needed to define background ranges for 8-OHdG, to use it as a measure of oxidative stress overproduction. We established a standardized protocol for a systematic review and meta-analysis to assess background ranges for urinary 8-OHdG concentrations in healthy populations. We computed geometric mean (GM) and geometric standard deviations (GSD) as the basis for the meta-analysis. We retrieved an initial 1246 articles, included 84 articles, and identified 128 study subgroups. We stratified the subgroups by body mass index, gender, and smoking status reported. The pooled GM value for urinary 8-OHdG concentrations in healthy adults with a mean body mass index (BMI) ≤ 25 measured using chemical methods was 3.9 ng/mg creatinine (interquartile range (IQR): 3 to 5.5 ng/mg creatinine). A significant positive association was observed between smoking and urinary 8-OHdG concentrations when measured by chemical analysis. No gender effect was observed.
Identifiants
pubmed: 32466448
pii: ijms21113743
doi: 10.3390/ijms21113743
pmc: PMC7313038
pii:
doi:
Substances chimiques
Biomarkers
0
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest
Références
Environ Int. 2017 May;102:87-96
pubmed: 28238459
Arch Toxicol. 2008 May;82(5):313-21
pubmed: 17912498
Can J Surg. 2014 Jun;57(3):183-7
pubmed: 24869610
FEBS Lett. 1997 Nov 3;417(1):150-2
pubmed: 9395094
Psychosom Med. 2018 Jan;80(1):28-33
pubmed: 28700458
J Hazard Mater. 2016 Sep 5;315:86-92
pubmed: 27179702
Eur J Clin Nutr. 2003 Sep;57(9):1135-40
pubmed: 12947433
Diabetes Metab Res Rev. 2004 Sep-Oct;20(5):399-404
pubmed: 15343586
PLoS One. 2015 Mar 05;10(3):e0119100
pubmed: 25741997
Obes Res Clin Pract. 2014 May-Jun;8(3):e201-98
pubmed: 24847669
Free Radic Res. 2006 Apr;40(4):379-84
pubmed: 16517502
FASEB J. 2010 Apr;24(4):1249-60
pubmed: 19966135
Cancer Sci. 2007 Aug;98(8):1254-8
pubmed: 17498199
Int J Biol Markers. 2015 Jul 22;30(3):e341-5
pubmed: 25588860
J Hazard Mater. 2009 Oct 30;170(2-3):699-704
pubmed: 19497668
Environ Sci Pollut Res Int. 2016 Jan;23(2):1284-99
pubmed: 26358213
Nutrition. 2016 Mar;32(3):321-31
pubmed: 26695876
Nucleic Acids Res. 1984 Feb 24;12(4):2127-36
pubmed: 6701096
Free Radic Res. 2013 Mar;47(3):181-91
pubmed: 23249116
Environ Res. 2019 Jun;173:306-317
pubmed: 30951957
Psychiatry Res. 2012 Dec 30;200(2-3):318-22
pubmed: 22732398
Med Princ Pract. 2011;20(2):187-90
pubmed: 21252578
Clin Toxicol (Phila). 2007 Jun-Aug;45(5):490-8
pubmed: 17503254
Occup Environ Med. 2011 Sep;68(9):653-8
pubmed: 21126960
Environ Int. 2019 Feb;123:382-389
pubmed: 30572170
Clin Biochem. 2013 Mar;46(4-5):321-6
pubmed: 23261837
Free Radic Res. 2011 Feb;45(2):147-55
pubmed: 20942574
Int J Environ Health Res. 2016;26(1):37-57
pubmed: 25742192
Mutat Res. 2003 Aug 5;539(1-2):9-18
pubmed: 12948810
Hum Exp Toxicol. 2009 Jun;28(6-7):331-8
pubmed: 19755444
Acta Med Iran. 2015;53(5):287-92
pubmed: 26024703
Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3351-7
pubmed: 19064550
Mol Genet Metab. 2011 Dec;104(4):644-7
pubmed: 21908221
Urol Res. 2007 Aug;35(4):185-91
pubmed: 17541572
Mutat Res. 1997 Dec;387(3):147-63
pubmed: 9439711
Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):986-96
pubmed: 24692499
Int J Environ Res Public Health. 2013 Dec 02;10(12):6662-71
pubmed: 24317383
Aging Clin Exp Res. 2016 Aug;28(4):625-32
pubmed: 26487663
Int J Environ Res Public Health. 2018 Aug 29;15(9):
pubmed: 30158499
Oxid Med Cell Longev. 2016;2016:6439037
pubmed: 27504148
J Nutr. 2009 Oct;139(10):1896-900
pubmed: 19692530
J Nutr. 2007 Dec;137(12):2717-22
pubmed: 18029489
Toxicol Lett. 2016 Jul 25;255:36-42
pubmed: 27208482
Inhal Toxicol. 2013 Jan;25(1):1-8
pubmed: 23293967
Int J Sports Med. 2008 Jan;29(1):27-33
pubmed: 17614024
J Clin Biochem Nutr. 2013 Mar;52(2):160-6
pubmed: 23524455
PLoS One. 2018 Oct 23;13(10):e0206176
pubmed: 30352092
Reprod Toxicol. 2005 Mar-Apr;19(4):487-92
pubmed: 15749262
Cancer Sci. 2016 Nov;107(11):1653-1659
pubmed: 27575995
Antioxid Redox Signal. 2011 Dec 1;15(11):2819-23
pubmed: 21689025
Arch Environ Occup Health. 2014;69(3):180-6
pubmed: 24325749
Exp Gerontol. 2005 Mar;40(3):173-80
pubmed: 15763394
Ann Otol Rhinol Laryngol. 2017 Feb;126(2):103-109
pubmed: 27780908
Exp Gerontol. 2004 Sep;39(9):1391-400
pubmed: 15489062
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
Antioxid Redox Signal. 2016 Apr 1;24(10):548-55
pubmed: 26650622
Circulation. 2012 Jul 31;126(5):598-603
pubmed: 22773454
N Engl J Med. 2002 Jun 20;346(25):1954-62
pubmed: 12075056
Biomed Environ Sci. 2012 Feb;25(1):109-16
pubmed: 22424635
Eur J Appl Physiol. 2012 Dec;112(12):4119-26
pubmed: 22526251
Clin Biochem. 2013 Nov;46(16-17):1717-22
pubmed: 24005081
Eur J Ophthalmol. 2008 Jan-Feb;18(1):94-8
pubmed: 18203092
Biochem Biophys Res Commun. 2013 Nov 1;440(4):725-30
pubmed: 24120947
BJU Int. 2008 May;101(9):1170-7
pubmed: 18241247
Medicine (Baltimore). 2015 Nov;94(45):e1872
pubmed: 26559255
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39
pubmed: 19412858
Syst Rev. 2016 Dec 5;5(1):210
pubmed: 27919275
Occup Environ Med. 2016 Feb;73(2):83-90
pubmed: 26491144
PLoS One. 2007 Oct 03;2(10):e991
pubmed: 17912368
Sci Total Environ. 2019 Feb 1;649:620-628
pubmed: 30176473
Free Radic Biol Med. 2011 Jan 15;50(2):254-61
pubmed: 21075202
Ecotoxicol Environ Saf. 2016 May;127:135-43
pubmed: 26827277
Environ Sci Pollut Res Int. 2016 Sep;23(17):17496-502
pubmed: 27230153
Int J Food Sci Nutr. 2011 Dec;62(8):844-50
pubmed: 21639820
Anticancer Res. 2013 Aug;33(8):3089-97
pubmed: 23898064
Proc Natl Acad Sci U S A. 1989 Dec;86(24):9697-701
pubmed: 2602371
Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):3-14
pubmed: 18199707
J Biol Chem. 1997 Aug 8;272(32):19633-6
pubmed: 9289489
J Clin Biochem Nutr. 2009 Mar;44(2):185-95
pubmed: 19308273
J Nutr. 2008 Aug;138(8):1567S-1571S
pubmed: 18641208
Clin Chim Acta. 2010 Mar;411(5-6):416-22
pubmed: 20035732
Free Radic Res. 1998 Dec;29(6):565-71
pubmed: 10098460
Toxicol Lett. 2020 Aug 1;328:19-27
pubmed: 32320775
Chem Biol Interact. 2014 Dec 5;224:164-75
pubmed: 25452175
Heliyon. 2020 Jan 07;6(1):e03138
pubmed: 32042943
Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1459-65
pubmed: 12433727
Nutr Metab (Lond). 2013 Oct 02;10(1):59
pubmed: 24499054
Cancer Epidemiol Biomarkers Prev. 2000 Jul;9(7):647-52
pubmed: 10919732
Clin Biochem. 2011 Jul;44(10-11):804-8
pubmed: 21601569
Chronobiol Int. 2002 Mar;19(2):423-39
pubmed: 12025934
Toxicol Lett. 2020 Jul 1;327:41-47
pubmed: 32234358
Int J Cardiol. 2015 Mar 15;183:214-20
pubmed: 25675904
Biochem Biophys Res Commun. 2006 Jun 9;344(3):906-11
pubmed: 16631617
Nutr Res. 2008 Feb;28(2):72-7
pubmed: 19083391
Environ Health Perspect. 2006 May;114(5):673-7
pubmed: 16675419
J Clin Epidemiol. 2009 Oct;62(10):1006-12
pubmed: 19631508
Antioxid Redox Signal. 2013 Jun 20;18(18):2377-91
pubmed: 23198723
J Nutr. 2003 Oct;133(10):3303S-3309S
pubmed: 14519830
Exp Ther Med. 2019 Apr;17(4):2757-2764
pubmed: 30930973
J Expo Sci Environ Epidemiol. 2018 Jan;28(1):76-83
pubmed: 28120834
Int J Mol Sci. 2012 Dec 10;13(12):16853-64
pubmed: 23222732
JMIR Res Protoc. 2019 Aug 02;8(8):e13744
pubmed: 31376276