Severe Multiorgan Failure Following Yellow Fever Vaccination.
multiorgan failure
vaccination
viscerotropic disease
yellow fever virus
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
26 May 2020
26 May 2020
Historique:
received:
14
02
2020
revised:
05
05
2020
accepted:
19
05
2020
entrez:
30
5
2020
pubmed:
30
5
2020
medline:
30
5
2020
Statut:
epublish
Résumé
The yellow fever (YF) vaccination is recommended by the WHO for people traveling or living in endemic areas at risk for yellow fever infections in Africa and South America. Although the live attenuated yellow fever vaccine is a safe and efficient vaccine, rare serious adverse events after vaccination have been reported. We present the case of a 74-year-old male with multiorgan failure after yellow fever vaccination for a trip to Brazil. The patient required admission to the intensive care unit with a prolonged stay due to severe organ dysfunction. Five days after the YF vaccination, the patient experienced nausea, vomiting, diarrhea, and general illness. Three days later he sought medical attention and was transferred to the University Hospital Heidelberg with beginning multiorgan failure and severe septic shock, including hypotonia, tachypnea, thrombopenia, and acute renal failure the same day. Within one week after vaccination, antibodies against YF virus were already detectable and progressively increased over the next two weeks. Viral RNA was detected in serum on the day of admission, with a viral load of 1.0 × 10 The risk for severe adverse events due to the YF vaccination should be balanced against the risk of acquiring a severe YF infection, especially in elderly travelers.
Sections du résumé
BACKGROUND
BACKGROUND
The yellow fever (YF) vaccination is recommended by the WHO for people traveling or living in endemic areas at risk for yellow fever infections in Africa and South America. Although the live attenuated yellow fever vaccine is a safe and efficient vaccine, rare serious adverse events after vaccination have been reported.
CASE PRESENTATION
METHODS
We present the case of a 74-year-old male with multiorgan failure after yellow fever vaccination for a trip to Brazil. The patient required admission to the intensive care unit with a prolonged stay due to severe organ dysfunction. Five days after the YF vaccination, the patient experienced nausea, vomiting, diarrhea, and general illness. Three days later he sought medical attention and was transferred to the University Hospital Heidelberg with beginning multiorgan failure and severe septic shock, including hypotonia, tachypnea, thrombopenia, and acute renal failure the same day. Within one week after vaccination, antibodies against YF virus were already detectable and progressively increased over the next two weeks. Viral RNA was detected in serum on the day of admission, with a viral load of 1.0 × 10
CONCLUSIONS
CONCLUSIONS
The risk for severe adverse events due to the YF vaccination should be balanced against the risk of acquiring a severe YF infection, especially in elderly travelers.
Identifiants
pubmed: 32466490
pii: vaccines8020249
doi: 10.3390/vaccines8020249
pmc: PMC7349955
pii:
doi:
Types de publication
Case Reports
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Emerg Infect Dis. 2001 Nov-Dec;7(6):945-51
pubmed: 11747720
Ther Adv Vaccines. 2013 Nov;1(4):144-52
pubmed: 24757521
Ocul Immunol Inflamm. 2019 Oct 11;:1-4
pubmed: 31603703
Expert Rev Vaccines. 2013 Nov;12(11):1351-68
pubmed: 24066727
Dtsch Med Wochenschr. 2017 Aug;142(16):1219-1222
pubmed: 28810279
BMC Infect Dis. 2018 Dec 29;18(1):707
pubmed: 30594124
J Clin Virol. 2005 Aug;33(4):274-80
pubmed: 16036176
J Travel Med. 2008 May-Jun;15(3):202-5
pubmed: 18494699
PLoS One. 2011;6(12):e27753
pubmed: 22163273
Vaccine. 2007 Dec 5;25(50):8480-5
pubmed: 18023511
J Clin Microbiol. 2011 Feb;49(2):760-2
pubmed: 21106799
Vaccine. 2005 May 9;23(25):3256-63
pubmed: 15837230
Trans R Soc Trop Med Hyg. 2007 Feb;101(2):169-75
pubmed: 16814821
Vaccine. 2006 Apr 5;24(15):2803-9
pubmed: 16464518
Vaccine. 2013 Dec 2;31(49):5798-805
pubmed: 24079979
J Neurovirol. 2018 Oct;24(5):642-646
pubmed: 29987579
Drug Des Devel Ther. 2016 Oct 12;10:3345-3353
pubmed: 27784992
Hum Vaccin. 2005 Sep-Oct;1(5):207-14
pubmed: 17012867
J Clin Virol. 2014 Nov;61(3):444-7
pubmed: 25223921
J Med Virol. 1998 Oct;56(2):159-67
pubmed: 9746073
J Travel Med. 2016 Jul 04;23(5):
pubmed: 27378369