Advances in Molecular Tools and In Vivo Models for the Study of Human Fungal Pathogenesis.
CRISPR
RNAi
animal models
fungal pathogens
genetic tools
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
26 May 2020
26 May 2020
Historique:
received:
15
04
2020
revised:
08
05
2020
accepted:
16
05
2020
entrez:
30
5
2020
pubmed:
30
5
2020
medline:
30
5
2020
Statut:
epublish
Résumé
Pathogenic fungi represent an increasing infectious disease threat to humans, especially with an increasing challenge of antifungal drug resistance. Over the decades, numerous tools have been developed to expedite the study of pathogenicity, initiation of disease, drug resistance and host-pathogen interactions. In this review, we highlight advances that have been made in the use of molecular tools using CRISPR technologies, RNA interference and transposon targeted mutagenesis. We also discuss the use of animal models in modelling disease of human fungal pathogens, focusing on zebrafish, the silkworm,
Identifiants
pubmed: 32466582
pii: microorganisms8060803
doi: 10.3390/microorganisms8060803
pmc: PMC7356103
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Medical Research Council
ID : MR/N006364/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N006364/2
Pays : United Kingdom
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