Systematic review and meta-analysis of mouse models of diabetes-associated ulcers.
laboratory research in diabetes
meta-analysis
transgenic and knockout mice
ulcer(s)
Journal
BMJ open diabetes research & care
ISSN: 2052-4897
Titre abrégé: BMJ Open Diabetes Res Care
Pays: England
ID NLM: 101641391
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
16
10
2019
revised:
29
02
2020
accepted:
18
04
2020
entrez:
30
5
2020
pubmed:
30
5
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
Mouse models are frequently used to study diabetes-associated ulcers, however, whether these models accurately simulate impaired wound healing has not been thoroughly investigated. This systematic review aimed to determine whether wound healing is impaired in mouse models of diabetes and assess the quality of the past research. A systematic literature search was performed of publicly available databases to identify original articles examining wound healing in mouse models of diabetes. A meta-analysis was performed to examine the effect of diabetes on wound healing rate using random effect models. A meta-regression was performed to examine the effect of diabetes duration on wound healing impairment. The quality of the included studies was also assessed using two newly developed tools. 77 studies using eight different models of diabetes within 678 non-diabetic and 720 diabetic mice were included. Meta-analysis showed that wound healing was impaired in all eight models. Meta-regression suggested that longer duration of diabetes prior to wound induction was correlated with greater degree of wound healing impairment. Pairwise comparisons suggested that non-obese diabetic mice exhibited more severe wound healing impairment compared with
Identifiants
pubmed: 32467222
pii: 8/1/e000982
doi: 10.1136/bmjdrc-2019-000982
pmc: PMC7259859
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Wound Repair Regen. 2012 Jul-Aug;20(4):512-22
pubmed: 22672117
Chem Biol Interact. 2018 Aug 1;291:55-64
pubmed: 29902415
Biochem Biophys Res Commun. 2016 Sep 23;478(3):1021-7
pubmed: 27431618
Lancet. 2005 Nov 12;366(9498):1719-24
pubmed: 16291066
ACS Chem Biol. 2014 Jan 17;9(1):105-10
pubmed: 24053680
Diabetes. 2016 Jul;65(7):2006-19
pubmed: 27207516
Nat Rev Nephrol. 2018 Jan;14(1):48-56
pubmed: 29062142
Diabetes. 2016 Mar;65(3):780-93
pubmed: 26718502
J Invest Dermatol. 2014 May;134(5):1446-1455
pubmed: 24326453
Br J Dermatol. 2010 Mar;162(3):478-86
pubmed: 19799605
J Invest Dermatol. 2015 Nov;135(11):2862-2870
pubmed: 26168231
Curr Diab Rep. 2018 Jan 23;18(1):2
pubmed: 29362914
Int J Clin Exp Pathol. 2012;5(1):1-11
pubmed: 22295141
Lipids Health Dis. 2017 Jan 17;16(1):12
pubmed: 28095860
J Surg Res. 2009 Jan;151(1):100-7
pubmed: 18619614
Front Immunol. 2017 Nov 24;8:1557
pubmed: 29225596
Diabetes. 2015 Jul;64(7):2593-602
pubmed: 25754958
N Engl J Med. 2017 Jun 15;376(24):2367-2375
pubmed: 28614678
Acta Biomater. 2014 Feb;10(2):843-57
pubmed: 24121197
Int J Biochem Cell Biol. 2002 Dec;34(12):1557-70
pubmed: 12379278
Atherosclerosis. 2007 Apr;191(2):241-9
pubmed: 16979174
PLoS One. 2017 May 23;12(5):e0178232
pubmed: 28542434
J Cell Physiol. 2016 Oct;231(10):2159-71
pubmed: 26825453
Inflammation. 2016 Apr;39(2):687-99
pubmed: 26650489
J Invest Dermatol. 2002 Jul;119(1):91-8
pubmed: 12164930
Adv Wound Care (New Rochelle). 2013 May;2(4):142-148
pubmed: 24527337
Plast Reconstr Surg. 2008 Jan;121(1):130-41
pubmed: 18176216
J Burn Care Rehabil. 1999 Mar-Apr;20(2):155-62
pubmed: 10188114
Exp Biol Med (Maywood). 2017 Mar;242(5):505-515
pubmed: 28211759
Lab Invest. 2017 Jul;97(7):782-791
pubmed: 28319086
Curr Protoc Pharmacol. 2015 Sep 01;70:5.47.1-5.47.20
pubmed: 26331889
Surgery. 1997 Apr;121(4):372-80
pubmed: 9122866
Cardiovasc Diabetol. 2018 Oct 23;17(1):138
pubmed: 30352589
Wound Repair Regen. 2011 Jul-Aug;19(4):481-6
pubmed: 21627711
Diabetes. 2016 Sep;65(9):2760-71
pubmed: 27217486
J Wound Care. 2017 Jul 1;26(Sup7):S24-S33
pubmed: 28704171
Diabetes Care. 2009 Dec;32(12):2193-9
pubmed: 19729524
Cell Physiol Biochem. 2012;29(3-4):571-82
pubmed: 22508064
Diabetes. 2016 Mar;65(3):633-46
pubmed: 26647385
J Invest Dermatol. 2008 Jun;128(6):1545-53
pubmed: 18239618
J Invest Dermatol. 2009 Sep;129(9):2265-74
pubmed: 19295612
Pharm Res. 1994 Jan;11(1):65-71
pubmed: 7511240
Diabet Med. 2018 May 23;:
pubmed: 29791033
Mol Immunol. 2018 Nov;103:322-335
pubmed: 30366166
Mol Ther. 2014 Apr;22(4):734-42
pubmed: 24394186
Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt A):1539-1551
pubmed: 30327197
PLoS One. 2018 Mar 13;13(3):e0193084
pubmed: 29534073
Cell Physiol Biochem. 2015;37(3):940-54
pubmed: 26381245
J Surg Res. 1994 Jun;56(6):562-70
pubmed: 8015312
Stem Cells Transl Med. 2012 Feb;1(2):125-35
pubmed: 23197759
Curr Atheroscler Rep. 2004 May;6(3):197-202
pubmed: 15068744
ILAR J. 2014;54(3):259-72
pubmed: 24615439
J Invest Dermatol. 2018 Jan;138(1):219-227
pubmed: 28899684
Wound Repair Regen. 2004 Jul-Aug;12(4):485-92
pubmed: 15260814
N Engl J Med. 2004 Jul 1;351(1):48-55
pubmed: 15229307
J Mol Histol. 2018 Jun;49(3):277-287
pubmed: 29637382
Cardiovasc Diabetol. 2016 Jun 18;15:88
pubmed: 27316923
Diabetologia. 2008 Feb;51(2):216-26
pubmed: 18087688
Nat Med. 2015 Jul;21(7):815-9
pubmed: 26076037
Diabetes Care. 2009 Jan;32 Suppl 1:S62-7
pubmed: 19118289
BMC Immunol. 2012 Jun 18;13:32
pubmed: 22708778
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
Int J Biol Macromol. 2017 Dec;105(Pt 1):45-55
pubmed: 28669805
Diabet Med. 2016 Nov;33(11):1493-1498
pubmed: 26666583
Wound Repair Regen. 2003 Mar-Apr;11(2):127-31
pubmed: 12631300
Photochem Photobiol. 2011 Nov-Dec;87(6):1433-41
pubmed: 21883243
Nat Rev Endocrinol. 2018 Mar;14(3):140-162
pubmed: 29348476
PLoS One. 2017 Jul 25;12(7):e0181832
pubmed: 28742839
Clin Sci (Lond). 2016 Jan;130(1):45-56
pubmed: 26443866
APMIS. 2010 Oct;118(10):753-64
pubmed: 20854469
Am J Physiol Renal Physiol. 2006 Jan;290(1):F214-22
pubmed: 16118394
Nat Commun. 2016 Nov 10;7:13393
pubmed: 27830702
Lipids Health Dis. 2013 Apr 01;12:46
pubmed: 23547923
Wound Repair Regen. 2007 Sep-Oct;15(5):636-45
pubmed: 17971009
Clin Sci (Lond). 2016 Feb;130(3):127-50
pubmed: 26678170
J Clin Invest. 2010 Dec;120(12):4207-19
pubmed: 21060152
J Am Soc Nephrol. 2005 Jan;16(1):27-45
pubmed: 15563560
Diabetes. 2014 May;63(5):1763-78
pubmed: 24487028
Cytokine. 2011 Nov;56(2):256-64
pubmed: 21803601
Biosci Rep. 2018 Mar 5;38(2):
pubmed: 29330224
Am J Pathol. 2015 Jun;185(6):1638-48
pubmed: 25871534
Neurobiol Dis. 2007 Dec;28(3):276-85
pubmed: 17804249
Diabetes. 2016 Oct;65(10):3091-103
pubmed: 27284113
BMJ Open. 2015 Nov 23;5(11):e008544
pubmed: 26597864
J Diabetes Complications. 2017 Jan;31(1):4-12
pubmed: 27839658
J Diabetes Complications. 2017 Sep;31(9):1363-1369
pubmed: 28720320
Am J Pathol. 2006 Oct;169(4):1167-82
pubmed: 17003476
PLoS One. 2012;7(8):e39373
pubmed: 22879874
Diabetologia. 2004 Jun;47(6):1047-54
pubmed: 15164170
Diabetologia. 1978 Mar;14(3):141-8
pubmed: 350680
J Ethnopharmacol. 2010 Sep 15;131(2):443-50
pubmed: 20633625
Arch Biochem Biophys. 2019 Jan;661:117-124
pubmed: 30458128
J Diabetes Res. 2014;2014:562625
pubmed: 25587545
J Invest Dermatol. 2015 Jan;135(1):269-278
pubmed: 25007043
Diabetologia. 2011 Apr;54(4):945-53
pubmed: 21165593
Curr Protoc Mouse Biol. 2016 Sep 01;6(3):223-255
pubmed: 27584552
Diabetologia. 2014 Sep;57(9):1947-56
pubmed: 24962668
Biochim Biophys Acta Mol Basis Dis. 2018 Jul;1864(7):2481-2494
pubmed: 29654945
Biochim Biophys Acta. 2014 Jan;1842(1):32-43
pubmed: 24161538
Int J Biochem Cell Biol. 1997 Jan;29(1):191-200
pubmed: 9076954
Mol Cell Endocrinol. 2019 Jan 15;480:74-82
pubmed: 30339820
J Nutr Biochem. 2013 Jan;24(1):88-96
pubmed: 22819564
Diabetes. 2005 Jul;54(7):2143-54
pubmed: 15983216
Nat Commun. 2018 Jan 2;9(1):33
pubmed: 29295997