The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis.
Proteolysis
affinity proteomics
degradomics
mitochondria function or biology
substrate identification
Journal
Molecular & cellular proteomics : MCP
ISSN: 1535-9484
Titre abrégé: Mol Cell Proteomics
Pays: United States
ID NLM: 101125647
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
08
04
2020
revised:
24
05
2020
pubmed:
30
5
2020
medline:
28
5
2021
entrez:
30
5
2020
Statut:
ppublish
Résumé
The mammalian mitochondrial proteome consists of more than 1100 annotated proteins and their proteostasis is regulated by only a few ATP-dependent protease complexes. Technical advances in protein mass spectrometry allowed for detailed description of the mitoproteome from different species and tissues and their changes under specific conditions. However, protease-substrate relations within mitochondria are still poorly understood. Here, we combined Terminal Amine Isotope Labeling of Substrates (TAILS) N termini profiling of heart mitochondria proteomes isolated from wild type and
Identifiants
pubmed: 32467259
pii: S1535-9476(20)34965-3
doi: 10.1074/mcp.RA120.002082
pmc: PMC8014998
pii:
doi:
Substances chimiques
Mitochondrial Proteins
0
Proteome
0
CLPP protein, mouse
EC 3.4.21.92
Endopeptidase Clp
EC 3.4.21.92
CLPX protein, mouse
EC 3.6.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1330-1345Informations de copyright
© 2020 Hofsetz et al.
Déclaration de conflit d'intérêts
Conflict of interest—Authors declare no competing interests.
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