Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk: A Prospective Study in the EPIC Cohort.

Adolescent Child Female Hormone Replacement Therapy / methods Humans Menstrual Cycle / physiology Pregnancy Prospective Studies Reproductive History Risk Factors

Journal

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608

Informations de publication

Date de publication:
08 2020
Historique:
received: 07 02 2020
revised: 07 04 2020
accepted: 19 05 2020
pubmed: 30 5 2020
medline: 25 11 2021
entrez: 30 5 2020
Statut: ppublish

Résumé

Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk. We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident urothelial carcinoma (overall and by tumor grade, tumor aggressiveness, and non-muscle-invasive urothelial carcinoma) risk were evaluated using Cox proportional hazards models. During a mean of 15 years of follow-up, 529 women developed urothelial carcinoma. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT), number of FTP was inversely associated with urothelial carcinoma risk (HR Our results support that increasing the number of FTP may reduce urothelial carcinoma risk. More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells.

Sections du résumé

BACKGROUND
Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk.
METHODS
We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident urothelial carcinoma (overall and by tumor grade, tumor aggressiveness, and non-muscle-invasive urothelial carcinoma) risk were evaluated using Cox proportional hazards models.
RESULTS
During a mean of 15 years of follow-up, 529 women developed urothelial carcinoma. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT), number of FTP was inversely associated with urothelial carcinoma risk (HR
CONCLUSIONS
Our results support that increasing the number of FTP may reduce urothelial carcinoma risk.
IMPACT
More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells.

Identifiants

DOI: 10.1158/1055-9965.EPI-20-0184 PMID: 32467345
pubmed: 32467345
pii: 1055-9965.EPI-20-0184
doi: 10.1158/1055-9965.EPI-20-0184
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1654-1664

Subventions

Organisme : Cancer Research UK
ID : C570/A16491
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M012190/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C8221/A19170
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 25004
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom

Informations de copyright

©2020 American Association for Cancer Research.

Auteurs

Leila Lujan-Barroso (L)

Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Gran Via de L'Hospitalet 199-203, L'Hospitalet de Llobregat, Barcelona, Spain. llujan@iconcologia.net.
Bellvitge Biomedical Research Institute - IDIBELL, Gran Via de L'Hospitalet 199-203, L'Hospitalet de Llobregat, Barcelona, Spain.
Department of Nursing of Public Health, Mental Health and Maternity and Child Health School of Nursing, Universitat de Barcelona, Carrer de la Feixa Llarga s/n, L'Hospitalet de Llobregat, Barcelona, Spain.
ORCID: 0000-0001-6224-1764

Edoardo Botteri (E)

Cancer Registry of Norway, Oslo University Hospital, Ullernchausseen 64, Oslo, Norway.
Norwegian National Advisory Unit for Women's Health, Women's Clinic, Oslo University Hospital, Sognsvannsveien 20, Oslo, Norway.

Saverio Caini (S)

Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, Florence, Italy.

Börje Ljungberg (B)

Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
ORCID: 0000-0002-4121-3753

Nina Roswall (N)

Diet, Genes and Environment, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, Denmark.
ORCID: 0000-0003-3071-1658

Anne Tjønneland (A)

Diet, Genes and Environment, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, Denmark.
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, Copenhagen, Denmark.
ORCID: 0000-0003-4385-2097

Bas Bueno-de-Mesquita (B)

Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, the Netherlands.
Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom.
Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, Kuala Lumpur, Malaysia.

Inger T Gram (IT)

Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
ORCID: 0000-0002-0031-4152

Rosario Tumino (R)

Department of Cancer Registry and Histopathology, "Civic -M.P. Arezzo" Hospital, ASP Ragusa, Ragusa, Italy.
ORCID: 0000-0003-2666-414X

Lambertus A Kiemeney (LA)

Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.
ORCID: 0000-0002-2368-1326

Fredrik Liedberg (F)

Department of Urology, Skåne University Hospital and Institution of Translational Medicine, Lund University, Jan Waldenströms gata 5, Malmö, Sweden.
ORCID: 0000-0001-8193-0370

Tanja Stocks (T)

Department of Clinical Sciences Lund, Lund University, Barngatan 4, Lund, Sweden.

Marc J Gunter (MJ)

International Agency for Research on Cancer/World Health Organization, Lyon, France.

Neil Murphy (N)

International Agency for Research on Cancer/World Health Organization, Lyon, France.

Iris Cervenka (I)

Inserm U1018, Centre for Research in Epidemiology and Population Health (CESP) "Health across Generations" Team, Gustave Roussy 114 rue Edouard Vaillant, Villejuif, France.

Agnès Fournier (A)

Inserm U1018, Centre for Research in Epidemiology and Population Health (CESP) "Health across Generations" Team, Gustave Roussy 114 rue Edouard Vaillant, Villejuif, France.
ORCID: 0000-0001-8380-3439

Marina Kvaskoff (M)

Inserm U1018, Centre for Research in Epidemiology and Population Health (CESP) "Health across Generations" Team, Gustave Roussy 114 rue Edouard Vaillant, Villejuif, France.
ORCID: 0000-0002-4557-3772

Christel Häggström (C)

Department of Biobank Research, Umeå University, Umeå, Sweden.
Department of Surgical Sciences, Uppsala University, Akademiska sjukhuset entrence 70, Uppsala, Sweden.

Kim Overvad (K)

Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.

Eiliv Lund (E)

Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.

Marit Waaseth (M)

Department of Pharmacy, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
ORCID: 0000-0002-1318-3972

Renée Turzanski Fortner (RT)

Division of Cancer Epidemiology, German Cancer Research Center (DFKZ), Im Neuenheimer Feld 280, Heidelberg, Germany.
ORCID: 0000-0002-1426-8505

Tilman Kühn (T)

Division of Cancer Epidemiology, German Cancer Research Center (DFKZ), Im Neuenheimer Feld 280, Heidelberg, Germany.

Virginia Menéndez (V)

Public Health Directorate, C/Ciriaco Miguel Virgil 9, Oviedo, Asturias, Spain.

Maria-Jose Sánchez (MJ)

Escuela Andaluza de Salud Pública (EASP), Cuesta del Observatorio 4, Granada, Spain.
Instituto de Investigación Biosanitaria ibs.GRANADA, Av. de las Fuerzas Armadas 2, Granada, Spain.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Av. Monforte de Lemos 3-5, Madrid, Spain.
Universidad de Granada, Av. del Hospicio 1, Granada, Spain.
ORCID: 0000-0003-4817-0757

Carmen Santiuste (C)

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Av. Monforte de Lemos 3-5, Madrid, Spain.
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Ronda de Levante 11, Murcia, Spain.

Aurora Perez-Cornago (A)

Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0002-5652-356X

Raul Zamora-Ros (R)

Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Gran Via de L'Hospitalet 199-203, L'Hospitalet de Llobregat, Barcelona, Spain.
Bellvitge Biomedical Research Institute - IDIBELL, Gran Via de L'Hospitalet 199-203, L'Hospitalet de Llobregat, Barcelona, Spain.
ORCID: 0000-0002-6236-6804

Amanda J Cross (AJ)

Faculty of Medicine, Imperial College London, Norfolk Place, London, United Kingdom.
ORCID: 0000-0002-0893-2377

Antonia Trichopoulou (A)

Hellenic Health Foundation, Kaisareias 13 & Alexandroupoleos, Athens, Greece.

Anna Karakatsani (A)

Hellenic Health Foundation, Kaisareias 13 & Alexandroupoleos, Athens, Greece.
2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece.
ORCID: 0000-0002-3275-2026

Eleni Peppa (E)

Hellenic Health Foundation, Kaisareias 13 & Alexandroupoleos, Athens, Greece.

Domenico Palli (D)

Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, Florence, Italy.
ORCID: 0000-0002-5558-2437

Vittorio Krogh (V)

Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumouri, Via Venezian 1, Milano, Italy.

Veronica Sciannameo (V)

Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (Turin), Italy.

Amalia Mattiello (A)

Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Via Pansini 5, Naples, Italy.

Salvatore Panico (S)

Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Via Pansini 5, Naples, Italy.

Carla H van Gils (CH)

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

N Charlotte Onland-Moret (NC)

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
ORCID: 0000-0002-2360-913X

Aurelio Barricarte (A)

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Av. Monforte de Lemos 3-5, Madrid, Spain.
Navarra Public Health Institute, C/Leyre 15, Pamplona, Spain.
Navarra Institute for Health Research (IdiSNA), C/Irunlarrea 3, Pamplona, Spain.
ORCID: 0000-0001-6750-1270

Pilar Amiano (P)

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Av. Monforte de Lemos 3-5, Madrid, Spain.
Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Research Institute, Paseo Doctor Begiristain s/N, 20014 Donostia/Gipuzkoa, Gipuzkoa, Spain.

Kay-Tee Khaw (KT)

Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom.

Heiner Boeing (H)

German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114 - 116, Nuthetal, Germany.

Elisabete Weiderpass (E)

International Agency for Research on Cancer/World Health Organization, Lyon, France.
ORCID: 0000-0003-2237-0128

Eric J Duell (EJ)

Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Gran Via de L'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Gran Via de L'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.
ORCID: 0000-0001-5256-0163

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Menstrual Factors, Reproductive History,...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Menstrual Factors, Reproductive History,...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Hormonothérapie substitutive › Menstrual Factors, Reproductive History,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Menstrual Factors, Reproductive History,...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Cycle menstruel › Menstrual Factors, Reproductive History,...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Menstrual Factors, Reproductive History,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Menstrual Factors, Reproductive History,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Antécédents gynécologiques et obstétricaux › Menstrual Factors, Reproductive History,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Menstrual Factors, Reproductive History,...