Targeting renal OATs to develop renal protective agent from traditional Chinese medicines: Protective effect of Apigenin against Imipenem-induced nephrotoxicity.
Apigenin
Imipenem
OATs
nephrotoxicity
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
23
12
2019
revised:
11
04
2020
accepted:
25
04
2020
pubmed:
30
5
2020
medline:
12
1
2021
entrez:
30
5
2020
Statut:
ppublish
Résumé
Imipenem (Imp) is a widely used broad-spectrum antibiotic. However, renal adverse effects limit its clinical application. We previously reported that organic anion transporters (OATs) facilitated the renal transport of Imp and contributed its nephrotoxicity. Natural flavonoids exhibited renal protective effect. Here, we aimed to develop potent OAT inhibitors from traditional Chinese medicines (TCMs) and to evaluate its protective effect against Imp-induced nephrotoxicity. Among 50 TCMs, Tribuli Fructus, Platycladi Cacumen, and Lycopi Herba exhibited potent inhibition on OAT1/3. After screening their main components, Apigenin strongly inhibited Imp uptake by OAT1/3-HEK293 cells with IC50 values of 1.98 ± 0.36 μM (OAT1) and 2.29 ± 0.88 μM (OAT3). Moreover, Imp exhibited OAT1/3-dependent cytotoxicity, which was alleviated by Apigenin. Furthermore, Apigenin ameliorated Imp-induced nephrotoxicity in rabbits, and reduced the renal secretion of Imp. Apigenin inhibited intracellular accumulation of Imp and sequentially decreased the nephrocyte toxicity in rabbit primary proximal tubule cells (rPTCs). Apigenin, a flavone widely distributed in TCMs, was a potent OAT1/3 inhibitor. Through OAT inhibition, at least in part, Apigenin decreased the renal exposure of Imp and consequently protected against the nephrotoxicity of Imp. Apigenin can be used as a promising agent to reduce the renal adverse reaction of Imp in clinic.
Substances chimiques
Organic Anion Transporters
0
Imipenem
71OTZ9ZE0A
Apigenin
7V515PI7F6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2998-3010Subventions
Organisme : National Natural Science Foundation of China
ID : 81874324
Organisme : National Natural Science Foundation of China
ID : 81903706
Organisme : National Natural Science Foundation of China
ID : U1608283
Organisme : Science and Technology Innovation Found
ID : 2018J12SN065
Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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