Suppression of TRPM7 enhances TRAIL-induced apoptosis in triple-negative breast cancer cells.

Antineoplastic Agents / pharmacology Apoptosis / genetics Breast Neoplasms / drug therapy Cell Line, Tumor Cell Movement / drug effects Cell Proliferation / drug effects Female Hepatic Stellate Cells / drug effects Humans Protein Kinase Inhibitors / pharmacology Protein Serine-Threonine Kinases / antagonists & inhibitors TRPM Cation Channels / antagonists & inhibitors Triple Negative Breast Neoplasms / drug therapy
TRAIL TRPM7 apoptosis c-FLIP triple-negative breast cancer

Journal

Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222

Informations de publication

Date de publication:
12 2020
Historique:
received: 04 10 2019
revised: 03 05 2020
accepted: 15 05 2020
pubmed: 30 5 2020
medline: 7 4 2021
entrez: 30 5 2020
Statut: ppublish

Résumé

Transient receptor potential cation channel subfamily M member 7 (TRPM7) composed of an ion channel and a kinase domain regulates triple-negative breast cancer (TNBC) cell migration, invasion, and metastasis, but it does not modulate TNBC proliferation. However, previous studies have shown that the combination treatment of nonselective TRPM7 channel inhibitors (2-aminoethoxydiphenyl borate and Gd

Identifiants

DOI: 10.1002/jcp.29820 PMID: 32468675
pubmed: 32468675
doi: 10.1002/jcp.29820
doi:

Substances chimiques

Antineoplastic Agents 0
Protein Kinase Inhibitors 0
TRPM Cation Channels 0
Protein Serine-Threonine Kinases EC 2.7.11.1
TRPM7 protein, human EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10037-10050

Informations de copyright

© 2020 Wiley Periodicals LLC.

Références

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Auteurs

Chiman Song (C)

Chemical Kinomics Research Center, Korea Institute of Science and Technology Seongbuk-gu, Seoul, Republic of Korea.
Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
ORCID: 0000-0002-4334-6218

Seunghye Choi (S)

KU-KIST Graduate School of Converging Science and Technology, Korea University, Seongbuk-gu, Seoul, Republic of Korea.

Ki-Bong Oh (KB)

Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.

Taebo Sim (T)

Chemical Kinomics Research Center, Korea Institute of Science and Technology Seongbuk-gu, Seoul, Republic of Korea.
KU-KIST Graduate School of Converging Science and Technology, Korea University, Seongbuk-gu, Seoul, Republic of Korea.
Severance Biomedical Science Institute, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Republic of Korea.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Cellules › Cellules étoilées du foie › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Canaux cationiques TRPM › Suppression of TRPM7 enhances TRAIL-induced...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Tumeurs du sein triple-négatives › Suppression of TRPM7 enhances TRAIL-induced...