FATCAT 2.0: towards a better understanding of the structural diversity of proteins.
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
02 07 2020
02 07 2020
Historique:
accepted:
19
05
2020
revised:
28
04
2020
received:
17
03
2020
pubmed:
30
5
2020
medline:
2
10
2020
entrez:
30
5
2020
Statut:
ppublish
Résumé
FATCAT 2.0 server (http://fatcat.godziklab.org/), provides access to a flexible protein structure alignment algorithm developed in our group. In such an alignment, rotations and translations between elements in the structure are allowed to minimize the overall root mean square deviation (RMSD) between the compared structures. This allows to effectively compare protein structures even if they underwent structural rearrangements in different functional forms, different crystallization conditions or as a result of mutations. The major update for the server introduces a new graphical interface, much faster database searches and several new options for visualization of the structural differences between proteins.
Identifiants
pubmed: 32469061
pii: 5848494
doi: 10.1093/nar/gkaa443
pmc: PMC7319568
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
W60-W64Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118187
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.
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