Reversal of Calcium Dysregulation as Potential Approach for Treating Alzheimer's Disease.
Alzheimer's disease
calcium hypothesis
cytosolic space
endoplasmic reticulum (ER)
nSOCE
therapeutic agents.
Journal
Current Alzheimer research
ISSN: 1875-5828
Titre abrégé: Curr Alzheimer Res
Pays: United Arab Emirates
ID NLM: 101208441
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
07
2019
revised:
25
02
2020
accepted:
11
05
2020
pubmed:
30
5
2020
medline:
5
8
2021
entrez:
30
5
2020
Statut:
ppublish
Résumé
Despite decades of research and effort, there is still no effective disease-modifying treatment for Alzheimer's Disease (AD). Most of the recent AD clinical trials were targeting amyloid pathway, but all these trials failed. Although amyloid pathology is a hallmark and defining feature of AD, targeting the amyloid pathway has been very challenging due to low efficacy and serious side effects. Alternative approaches or mechanisms for our understanding of the major cause of memory loss in AD need to be considered as potential therapeutic targets. Increasing studies suggest that Ca2+ dysregulation in AD plays an important role in AD pathology and is associated with other AD abnormalities, such as excessive inflammation, increased ROS, impaired autophagy, neurodegeneration, synapse, and cognitive dysfunction. Ca2+ dysregulation in cytosolic space, Endoplasmic Reticulum (ER) and mitochondria have been reported in the context of various AD models. Drugs or strategies, to correct the Ca2+ dysregulation in AD, have been demonstrated to be promising as an approach for the treatment of AD in preclinical models. This review will discuss the mechanisms of Ca2+ dysregulation in AD and associated pathology and discuss potential approaches or strategies to develop novel drugs for the treatment of AD by targeting Ca2+ dysregulation.
Identifiants
pubmed: 32469698
pii: CAR-EPUB-106963
doi: 10.2174/1567205017666200528162046
pmc: PMC8210816
mid: NIHMS1678186
doi:
Substances chimiques
Calcium Channel Blockers
0
Intracellular Calcium-Sensing Proteins
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
344-354Subventions
Organisme : NIA NIH HHS
ID : RF1 AG055577
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052557
Pays : United States
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Références
J Biomed Sci. 2020 Jan 6;27(1):18
pubmed: 31906949
J Cell Biol. 2008 Jun 30;181(7):1107-16
pubmed: 18591429
Biochim Biophys Acta. 2009 Jun;1793(6):1050-7
pubmed: 19111578
Neuron. 2009 Aug 13;63(3):287-303
pubmed: 19679070
Cell Res. 2011 Feb;21(2):305-15
pubmed: 20838418
J Alzheimers Dis. 2010;21(3):781-93
pubmed: 20634584
Brain Res Bull. 2009 Mar 16;78(4-5):152-7
pubmed: 19000747
J Biol Chem. 2000 Jun 16;275(24):18195-200
pubmed: 10764737
Eur J Pharmacol. 2014 Sep 15;739:83-95
pubmed: 24316360
Acta Naturae. 2010 Apr;2(1):72-82
pubmed: 22649630
Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27
pubmed: 23776240
Neurobiol Dis. 2011 Jan;41(1):62-70
pubmed: 20816785
J Neurochem. 2016 Oct;139 Suppl 2:237-252
pubmed: 27255958
FEBS Lett. 2014 Aug 25;588(17):2874-80
pubmed: 24996186
Neuropharmacology. 2014 Jan;76 Pt A:16-26
pubmed: 23973316
Recent Pat Biotechnol. 2012 Dec;6(3):157-66
pubmed: 23092431
Alzheimer Dis Assoc Disord. 2015 Jan-Mar;29(1):1-5
pubmed: 25551862
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Biol Psychiatry. 2013 Aug 15;74(4):250-6
pubmed: 22840761
J Alzheimers Dis. 2015;45(2):561-80
pubmed: 25589721
J Biol Chem. 2010 Apr 23;285(17):12463-8
pubmed: 20212036
Pflugers Arch. 2010 Feb;459(3):441-9
pubmed: 19795132
Neurology. 2009 Mar 3;72(9):829-34
pubmed: 19255410
Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1807-16
pubmed: 23620513
Nature. 2013 Jan 3;493(7430):56-61
pubmed: 23254940
Nat Cell Biol. 2006 Jul;8(7):771-3
pubmed: 16733527
Nature. 2015 Sep 10;525(7568):212-217
pubmed: 26280335
Neurobiol Learn Mem. 2017 Feb;138:54-61
pubmed: 27544849
Neuron. 2014 Apr 2;82(1):79-93
pubmed: 24698269
Neurol Sci. 2016 Jul;37(7):1039-47
pubmed: 26971324
Int J Biochem Cell Biol. 2008;40(1):84-97
pubmed: 17709274
Alzheimers Dement. 2017 Feb;13(2):178-182.e17
pubmed: 28061328
Behav Brain Res. 2015 Mar 15;281:69-77
pubmed: 25513972
Biochem Biophys Res Commun. 2017 Feb 19;483(4):998-1004
pubmed: 27641664
Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1071-1087
pubmed: 27913207
Bioorg Med Chem Lett. 2019 Mar 15;29(6):761-777
pubmed: 30709653
Nature. 2019 Jan;565(7738):192-197
pubmed: 30598546
Int J Alzheimers Dis. 2010 Dec 28;2011:950932
pubmed: 21253550
Neuron. 2010 Jun 10;66(5):739-54
pubmed: 20547131
J Neurosci. 2016 Nov 23;36(47):11837-11850
pubmed: 27881772
Nat Biotechnol. 2015 Oct;33(10):1092-6
pubmed: 26368050
J Neurosci Res. 2002 Feb 1;67(3):379-87
pubmed: 11813243
J Clin Invest. 2008 Jun;118(6):2230-45
pubmed: 18483626
Neurochem Int. 2009 Jan;54(1):49-55
pubmed: 19013491
J Biol Chem. 2003 Jan 24;278(4):2484-9
pubmed: 12431992
Biochem Biophys Res Commun. 2006 Dec 1;350(4):969-76
pubmed: 17045966
J Biol Chem. 2006 Dec 15;281(50):38440-7
pubmed: 17050533
Neuroscience. 2003;116(2):437-45
pubmed: 12559098
J Neurosci. 2015 Sep 30;35(39):13275-86
pubmed: 26424877
Mol Biol Cell. 2015 Mar 15;26(6):1141-59
pubmed: 25609091
Trends Pharmacol Sci. 2001 Jun;22(6):292-7
pubmed: 11395157
PLoS One. 2011 Apr 26;6(4):e19285
pubmed: 21541286
Cell. 2007 Dec 28;131(7):1327-39
pubmed: 18160041
Nat Neurosci. 2008 Jul;11(7):741-3
pubmed: 18516035
J Neurosci. 2013 Feb 27;33(9):3824-33
pubmed: 23447594
J Pharmacol Exp Ther. 2017 Jul;362(1):31-44
pubmed: 28416568
Neurosci Lett. 2012 May 16;516(2):274-9
pubmed: 22516463
J Neurosci. 2014 May 14;34(20):6910-23
pubmed: 24828645
J Cell Biol. 1995 Mar;128(5):893-904
pubmed: 7876312
Cell Signal. 2005 Apr;17(4):437-45
pubmed: 15601622
Nature. 2002 Apr 4;416(6880):535-9
pubmed: 11932745
Acta Neuropathol. 2017 Nov;134(5):749-767
pubmed: 28631094
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):567-71
pubmed: 8380642
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4697-702
pubmed: 11917117
Curr Alzheimer Res. 2010 Mar;7(2):126-33
pubmed: 19939230
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8098-102
pubmed: 8367470
J Alzheimers Dis. 2013;37(4):735-46
pubmed: 23948911
Cell Calcium. 2019 May;79:44-56
pubmed: 30822648
J Neurosci. 2007 Dec 12;27(50):13719-29
pubmed: 18077683
Sci Signal. 2010 Mar 23;3(114):ra22
pubmed: 20332427
Front Behav Neurosci. 2015 Jul 14;9:180
pubmed: 26236206
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
Transl Psychiatry. 2011 Jul 12;1:e20
pubmed: 22832522
J Neurosci. 2006 May 10;26(19):5180-9
pubmed: 16687509
J Neural Transm Park Dis Dement Sect. 1991;3(4):231-58
pubmed: 1772577
Adv Exp Med Biol. 2016;898:87-109
pubmed: 27161226
J Biol Chem. 2006 Jul 28;281(30):20661-20665
pubmed: 16766533
Mol Pain. 2014 Jun 26;10:43
pubmed: 24965271
Nat Med. 2016 Mar;22(3):238-49
pubmed: 26937618
Science. 2019 Feb 15;363(6428):
pubmed: 30630874
J Biol Chem. 2009 Jul 17;284(29):19164-8
pubmed: 19487696
J Biol Chem. 2006 Nov 24;281(47):35855-62
pubmed: 17020874
Arch Intern Med. 2002 Oct 14;162(18):2046-52
pubmed: 12374512
J Exp Med. 2015 Mar 9;212(3):287-95
pubmed: 25732305
Sci Signal. 2009 Oct 20;2(93):ra67
pubmed: 19843959
Neuron. 2000 Sep;27(3):561-72
pubmed: 11055438
PLoS One. 2012;7(12):e52056
pubmed: 23284867
J Neurosci. 2009 Jan 28;29(4):1017-33
pubmed: 19176811
Sci Signal. 2016 Sep 06;9(444):ra89
pubmed: 27601731
J Neurosci. 2006 May 31;26(22):6011-8
pubmed: 16738244
Neuron. 2008 Jun 26;58(6):871-83
pubmed: 18579078
J Neurochem. 2013 Nov;127(3):303-13
pubmed: 23875811
Cell Calcium. 2003 Oct-Nov;34(4-5):339-44
pubmed: 12909080
Biochem Biophys Res Commun. 2017 Feb 19;483(4):988-997
pubmed: 27659710
J Neurosci. 2010 Jun 23;30(25):8566-80
pubmed: 20573903
J Alzheimers Dis. 2013;33 Suppl 1:S277-81
pubmed: 22635102
J Biol Chem. 2011 Jun 24;286(25):22339-47
pubmed: 21531718
Neuroscience. 2019 Jul 1;410:118-127
pubmed: 31055008
J Geriatr Psychiatry Neurol. 1994 Oct;7 Suppl 1:S34-8
pubmed: 7857506
Neuroscience. 2003;122(2):291-303
pubmed: 14614897
J Neurosci Res. 2011 Aug;89(8):1235-44
pubmed: 21538465
PLoS One. 2012;7(9):e43557
pubmed: 23028459
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13299-304
pubmed: 21788510
Neurodegener Dis. 2014;13(2-3):139-41
pubmed: 24080896
J Neurochem. 2013 Sep;126(6):727-38
pubmed: 23711249
Curr Biol. 2005 Jul 12;15(13):1235-41
pubmed: 16005298
Aging Cell. 2007 Jun;6(3):307-17
pubmed: 17465978
Receptors Clin Investig. 2015;2(1):e449
pubmed: 25646163
Cell. 2014 Nov 6;159(4):721-6
pubmed: 25417150
J Am Chem Soc. 2015 Aug 26;137(33):10516-9
pubmed: 26252484
Adv Exp Med Biol. 2011;704:435-49
pubmed: 21290310
Mol Neurodegener. 2015 Aug 15;10:37
pubmed: 26275606
Am J Physiol Cell Physiol. 2011 Jun;300(6):C1502-12
pubmed: 21368296
Mol Cell Neurosci. 2008 Apr;37(4):673-81
pubmed: 18272392
J Neurosci. 2010 Sep 8;30(36):12128-37
pubmed: 20826675
Int J Alzheimers Dis. 2010 Dec 27;2011:720658
pubmed: 21234369
Ann N Y Acad Sci. 1989;568:1-4
pubmed: 2629579
Mol Pharmacol. 2019 Apr;95(4):337-348
pubmed: 30696719
PLoS One. 2012;7(3):e33377
pubmed: 22438918
J Neurosci. 2003 Aug 27;23(21):7737-41
pubmed: 12944501
Biol Psychiatry. 2000 Feb 15;47(4):351-4
pubmed: 10686270
J Biol Chem. 2010 Jul 16;285(29):22437-47
pubmed: 20436167
J Biol Chem. 2005 Apr 29;280(17):17294-300
pubmed: 15722360
Behav Brain Res. 2017 Mar 30;322(Pt B):223-232
pubmed: 27180169
Nature. 2005 Oct 6;437(7060):902-5
pubmed: 16208375
Cell. 2006 Sep 8;126(5):981-93
pubmed: 16959576
Chem Biol. 2011 Jun 24;18(6):777-93
pubmed: 21700213
J Biol Chem. 2006 Nov 3;281(44):33477-86
pubmed: 16945924
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15091-6
pubmed: 23918386
Front Aging Neurosci. 2019 Jul 24;11:186
pubmed: 31396078
J Neurosci. 2012 Jun 13;32(24):8341-53
pubmed: 22699914
J Biol Chem. 1999 Jul 23;274(30):21395-401
pubmed: 10409701
Ann Neurol. 2019 May;85(5):726-739
pubmed: 30840313
Trends Neurosci. 2008 Sep;31(9):454-63
pubmed: 18675468
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4682-7
pubmed: 17360584
Cell Calcium. 2014 Apr;55(4):219-29
pubmed: 24656753
Mol Psychiatry. 2006 Nov;11(11):1032-48
pubmed: 16880827
J Clin Invest. 2007 May;117(5):1230-9
pubmed: 17431506
Int J Neuropsychopharmacol. 2013 Feb;16(1):189-98
pubmed: 22226089
J Neurosci. 2009 Jul 29;29(30):9458-70
pubmed: 19641109
Nat Commun. 2015 Nov 19;6:8876
pubmed: 26581893
J Neurosci. 2012 Aug 22;32(34):11820-34
pubmed: 22915123
Int J Mol Sci. 2018 Apr 11;19(4):
pubmed: 29641484
J Alzheimers Dis. 2015;45(1):75-88
pubmed: 25537011
Neuron. 2008 Jul 31;59(2):214-25
pubmed: 18667150
Mol Psychiatry. 2018 Mar;23(3):767-776
pubmed: 28696436
Sci Transl Med. 2011 Jun 29;3(89):89ra57
pubmed: 21715678
Cell Calcium. 2008 Nov;44(5):507-18
pubmed: 18440065
J Cell Biol. 2000 May 15;149(4):793-8
pubmed: 10811821
J Alzheimers Dis. 2013;34(4):873-85
pubmed: 23302657
FASEB J. 2007 Dec;21(14):4101-11
pubmed: 17666455
Anaesthesia. 2004 Apr;59(4):364-73
pubmed: 15023108
Front Cell Neurosci. 2013 Jul 30;7:120
pubmed: 23908603
Neurodegener Dis Manag. 2015 Oct;5(5):395-8
pubmed: 26477700
Hereditas. 2019 Jul 16;156:25
pubmed: 31346329
J Physiol. 2017 Jan 1;595(1):125-140
pubmed: 27393042
Clin Interv Aging. 2009;4:367-77
pubmed: 19851512
Mol Neurodegener. 2014 Jun 05;9:21
pubmed: 24902695
Neurobiol Aging. 2013 Dec;34(12):2699-714
pubmed: 23855984