Development of Humanized Ossicles: Bridging the Hematopoietic Gap.

Animals Bone Marrow Cells / physiology Bone and Bones / physiology Hematopoiesis / physiology Hematopoietic Stem Cells / physiology Humans Mesenchymal Stem Cells / physiology Stem Cell Niche / physiology
bone marrow niche bone tissue engineering hematopoiesis hematopoietic stem cells humanized ossicle mesenchymal stromal cells

Journal

Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035

Informations de publication

Date de publication:
06 2020
Historique:
received: 25 11 2019
revised: 16 01 2020
accepted: 31 01 2020
entrez: 30 5 2020
pubmed: 30 5 2020
medline: 9 7 2021
Statut: ppublish

Résumé

Ectopic 'humanized ossicles' (hOss) are miniaturized, engineered human bone organs in mice displaying a similar structure and function to native mouse bones. However, they are composed of human mesenchymal derived cells forming a humanized bone marrow niche. This in vivo reconstitution of human skeletal and hematopoietic compartments provides an opportunity to investigate the cellular and molecular processes involved in their establishment and functions in a human setting. However, current hOs strategies vary in their engineering methods and their downstream applications, undermining comprehensive exploitation of their potential. This review describes the specificities of the hOs models and highlights their potential and limits. Ultimately, we propose directions for the development of hOss as a technological platform for human hematopoietic studies.

Identifiants

DOI: 10.1016/j.molmed.2020.01.016 PMID: 32470383
pubmed: 32470383
pii: S1471-4914(20)30044-7
doi: 10.1016/j.molmed.2020.01.016
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

552-569

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Steven J Dupard (SJ)

Laboratory for Cell, Tissue, and Organ engineering, Department of Clinical Sciences, Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden; Stem Cell Center, Lund University, Lund, Sweden.

Ani Grigoryan (A)

Laboratory for Cell, Tissue, and Organ engineering, Department of Clinical Sciences, Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden; Stem Cell Center, Lund University, Lund, Sweden.

Stephanie Farhat (S)

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Division of Orthopedic Surgery, The Ottawa Hospital, Ottawa, ON, Canada.

Daniel L Coutu (DL)

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Division of Orthopedic Surgery, The Ottawa Hospital, Ottawa, ON, Canada.

Paul E Bourgine (PE)

Laboratory for Cell, Tissue, and Organ engineering, Department of Clinical Sciences, Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden; Stem Cell Center, Lund University, Lund, Sweden. Electronic address: paul.bourgine@med.lu.se.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Development of Humanized Ossicles: Bridging...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Development of Humanized Ossicles: Bridging...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Development of Humanized Ossicles: Bridging...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Development of Humanized Ossicles: Bridging...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Development of Humanized Ossicles: Bridging...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Development of Humanized Ossicles: Bridging...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Development of Humanized Ossicles: Bridging...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Niche de cellules souches › Development of Humanized Ossicles: Bridging...