Propagation of Pathological α-Synuclein from the Urogenital Tract to the Brain Initiates MSA-like Syndrome.
Behavioral Neuroscience
Biological Sciences
Neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
26 Jun 2020
26 Jun 2020
Historique:
received:
17
07
2019
revised:
29
12
2019
accepted:
08
05
2020
pubmed:
30
5
2020
medline:
30
5
2020
entrez:
30
5
2020
Statut:
ppublish
Résumé
The neuropathological feature of multiple system atrophy (MSA), a fatal adult-onset disorder without effective therapy, is the accumulation of pathological α-synuclein (α-Syn) in the central nervous system (CNS). Here we show that pathological α-Syn exists in nerve terminals in detrusor and external urethral sphincter (EUS) of patients with MSA. Furthermore, α-Syn-preformed fibrils (PFFs) injected in the EUS or detrusor in TgM83
Identifiants
pubmed: 32470898
pii: S2589-0042(20)30351-5
doi: 10.1016/j.isci.2020.101166
pmc: PMC7260590
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101166Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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