Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation.
AMPK activators
IK(Ca) channels
K(ATP) channels
Reactive oxygen species
Renal arteries
SERCA
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
09
04
2020
accepted:
10
05
2020
pubmed:
30
5
2020
medline:
22
6
2021
entrez:
30
5
2020
Statut:
ppublish
Résumé
AMP-activated protein kinase (AMPK) is a cellular energy sensor activated during energy stress to stimulate ATP production pathways and restore homeostasis. AMPK is widely expressed in the kidney and involved in mitochondrial protection and biogenesis upon acute renal ischemia, AMPK activity being blunted in metabolic disease-associated kidney disease. Since little is known about AMPK in the regulation of renal blood flow, the present study aimed to assess the role of AMPK in renal vascular function. Functional responses to the selective AMPK activator A769662 were assessed in intrarenal small arteries isolated from the kidney of renal tumour patients and Wistar rats and mounted in microvascular myographs to perform simultaneous measurements of intracellular calcium [Ca
Identifiants
pubmed: 32470915
pii: S2213-2317(20)30554-1
doi: 10.1016/j.redox.2020.101575
pmc: PMC7256643
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Adenosine Monophosphate
415SHH325A
Hydrogen Peroxide
BBX060AN9V
AMP-Activated Protein Kinases
EC 2.7.11.31
Adenylate Kinase
EC 2.7.4.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101575Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest All authors declare no competing interests.
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