Association of serum interleukin-6 and soluble interleukin-2-receptor levels with disease activity status in patients with inflammatory bowel disease: A prospective observational study.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
01
2020
accepted:
12
05
2020
entrez:
30
5
2020
pubmed:
30
5
2020
medline:
18
8
2020
Statut:
epublish
Résumé
Crohn's disease (CD) and ulcerative colitis (UC) are characterized by overexpression of proinflammatory cytokines. We determined the association of serum levels of interleukin (IL)-6, soluble-IL-2-receptor (sIL-2R) and CRP as well as of faecal calprotectin (FC) values with disease activity in CD and UC patients. This prospective study included 145 CD and 84 UC patients. Serum proinflammatory biomarkers and FC levels were measured and demographic, clinical and endoscopic characteristics were collected. Uni- and multivariate statistical analyses were performed. Serum IL-6 and CRP levels as well as FC values of CD patients were associated with clinical and endoscopic remission. In multivariate analysis serum IL-6 levels remained significantly associated with clinical and endoscopic remission. FC levels were also associated with endoscopic remission in CD patients. CD patients under the threshold levels of 8.5 pg/mL and 5.5 pg/mL for serum IL-6 were in 70% and 66% in clinical and endoscopic remission, respectively. Serum sIL-2R, CRP levels and FC values of UC patients were associated in univariate analysis with clinical and endoscopic remission. In multivariate analysis CRP and FC values were associated with clinical remission and serum sIL-2R as well as FC levels with endoscopic remission. UC patients under the threshold levels of 759 IU/mL and 646 IU/mL for serum sIL-2R were in 76% and 76% in clinical and endoscopic remission, respectively. Beside CRP and FC, serum IL-6 levels in CD patients and sIL-2R levels in UC patients can be a further useful non-invasive biomarker to identify the disease activity status.
Identifiants
pubmed: 32470973
doi: 10.1371/journal.pone.0233811
pii: PONE-D-20-02810
pmc: PMC7259981
doi:
Substances chimiques
Interleukin-6
0
Leukocyte L1 Antigen Complex
0
Receptors, Interleukin-2
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0233811Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Immunol. 2010 Nov 1;185(9):5512-21
pubmed: 20870936
Clin Gastroenterol Hepatol. 2016 Jun;14(6):818-824.e6
pubmed: 26844874
Am J Gastroenterol. 2015 Jun;110(6):802-19; quiz 820
pubmed: 25964225
Ann Intern Med. 1990 Oct 15;113(8):619-27
pubmed: 2205142
Can J Gastroenterol. 2005 Sep;19 Suppl A:5A-36A
pubmed: 16151544
J Crohns Colitis. 2019 Feb 1;13(2):144-164
pubmed: 30137275
Gastroenterology. 2018 Aug;155(2):303-306.e2
pubmed: 29775600
PLoS One. 2019 Oct 24;14(10):e0223893
pubmed: 31647834
Eur J Gastroenterol Hepatol. 1997 Feb;9(2):173-7
pubmed: 9058629
J Clin Gastroenterol. 1996 Jul;23(1):40-3
pubmed: 8835898
Inflamm Bowel Dis. 2017 Jan;23(1):158-164
pubmed: 27930409
Nature. 2011 Jun 15;474(7351):307-17
pubmed: 21677747
Gastroenterol Jpn. 1991 Feb;26(1):20-8
pubmed: 2007457
Gastroenterology. 2015 Oct;149(5):1275-1285.e2
pubmed: 26166315
Gastroenterology. 1992 Jun;102(6):2006-14
pubmed: 1587419
J Pediatr Gastroenterol Nutr. 2010 Jan;50(1):22-6
pubmed: 19934771
J Crohns Colitis. 2018 Jan 5;12(1):87-95
pubmed: 28961693
J Cell Biol. 1986 Sep;103(3):787-93
pubmed: 3017995
Gastrointest Endosc. 2004 Oct;60(4):505-12
pubmed: 15472670
Semin Immunol. 2014 Feb;26(1):2-12
pubmed: 24325804
Am J Gastroenterol. 2015 Sep;110(9):1324-38
pubmed: 26303131
J Immunol. 1986 Dec 15;137(12):3841-4
pubmed: 3023487
Lancet. 1980 Mar 8;1(8167):514
pubmed: 6102236
Nat Rev Immunol. 2014 May;14(5):329-42
pubmed: 24751956
Eur J Gastroenterol Hepatol. 1997 Oct;9(10):939-44
pubmed: 9391781
Nature. 2007 Jul 26;448(7152):427-34
pubmed: 17653185
Medicine (Baltimore). 2019 Apr;98(15):e15172
pubmed: 30985701
Int J Colorectal Dis. 2018 Jul;33(7):927-936
pubmed: 29748708
J Immunol. 1985 Nov;135(5):3172-7
pubmed: 3930598
Am J Gastroenterol. 1995 Aug;90(8):1301-6
pubmed: 7639234
Gut. 1991 Dec;32(12):1531-4
pubmed: 1773961
Inflamm Bowel Dis. 2008 Dec;14(12):1660-6
pubmed: 18623174