Low prevalence and disease severity of COVID-19 in post-liver transplant recipients-A single centre experience.
COVID-19
immunosuppression
liver transplant
Journal
Liver international : official journal of the International Association for the Study of the Liver
ISSN: 1478-3231
Titre abrégé: Liver Int
Pays: United States
ID NLM: 101160857
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
06
05
2020
revised:
26
05
2020
accepted:
27
05
2020
pubmed:
30
5
2020
medline:
18
11
2020
entrez:
30
5
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is driving a present day global pandemic. Immunosuppressed patients are regarded as a high-risk cohort. The following is a short report on COVID-19 in liver transplant recipients (n = 5) from a high volume UK liver transplant unit with a large follow-up cohort (n = 4500). Based on this limited data, liver transplant recipients appear to have a low incidence of COVID-19, with less severe symptoms than expected, when compared with the general population and other solid organ recipients. This possibly could be related to self-isolation adherence and/or the 'ideal' level of immunosuppression that favourably modulates the immune response to COVID-19.
Identifiants
pubmed: 32471013
doi: 10.1111/liv.14552
pmc: PMC7300707
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1972-1976Informations de copyright
© 2020 The Authors. Liver International published by John Wiley & Sons Ltd.
Références
Am J Transplant. 2020 Jul;20(7):1902-1906
pubmed: 32324331
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Viruses. 2013 May 22;5(5):1250-60
pubmed: 23698397
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Lancet Gastroenterol Hepatol. 2020 Jun;5(6):532-533
pubmed: 32278366
Am J Transplant. 2020 Jul;20(7):1875-1878
pubmed: 32198834
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Transplantation. 2020 Oct;104(10):1974-1983
pubmed: 32243281
Liver Int. 2020 Aug;40(8):1972-1976
pubmed: 32471013
Metabolism. 2020 Jul;108:154244
pubmed: 32320741
Age Ageing. 2020 Jul 1;49(4):523-524
pubmed: 32315386
Virus Res. 2012 Apr;165(1):112-7
pubmed: 22349148
Liver Transpl. 2020 Jun;26(6):832-834
pubmed: 32196933
Clin Immunol. 2020 Jun;215:108427
pubmed: 32325252
Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975
pubmed: 32350134