Shedding Light on the Role of Extracellular Vesicles in HIV Infection and Wound Healing.
AIDS
HIV
exosomes
extracellular vesicles
immune response
wound healing
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
27 05 2020
27 05 2020
Historique:
received:
27
04
2020
revised:
19
05
2020
accepted:
25
05
2020
entrez:
31
5
2020
pubmed:
31
5
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Extracellular vesicles (EVs) play an important role in intercellular communication. They are naturally released from cells into the extracellular environment. Based on their biogenesis, release pathways, size, content, and function, EVs are classified into exosomes, microvesicles (MVs), and apoptotic bodies (ApoBDs). Previous research has documented that EVs, specifically exosomes and MVs, play an important role in HIV infection, either by promoting HIV infection and pathogenesis or by inhibiting HIV-1 to a certain extent. We have also previously reported that EVs (particularly exosomes) from vaginal fluids inhibit HIV at the post-entry step (i.e., reverse transcription, integration). Besides the role that EVs play in HIV, they are also known to regulate the process of wound healing by regulating both the immune and inflammatory responses. It is noted that during the advanced stages of HIV infection, patients are at greater risk of wound-healing and wound-related complications. Despite ongoing research, the data on the actual effects of EVs in HIV infection and wound healing are still premature. This review aimed to update the current knowledge about the roles of EVs in regulating HIV pathogenesis and wound healing. Additionally, we highlighted several avenues of EV involvement in the process of wound healing, including coagulation, inflammation, proliferation, and extracellular matrix remodeling. Understanding the role of EVs in HIV infection and wound healing could significantly contribute to the development of new and potent antiviral therapeutic strategies and approaches to resolve impaired wounds in HIV patients.
Identifiants
pubmed: 32471020
pii: v12060584
doi: 10.3390/v12060584
pmc: PMC7354510
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDA NIH HHS
ID : R01 DA041746
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA033924
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI102684
Pays : United States
Organisme : NIDA NIH HHS
ID : R03 DA033900
Pays : United States
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