E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis.
angiogenesis
e-cigarettes
embryo
gene deregulations
toxicity
Journal
Toxics
ISSN: 2305-6304
Titre abrégé: Toxics
Pays: Switzerland
ID NLM: 101639637
Informations de publication
Date de publication:
27 May 2020
27 May 2020
Historique:
received:
28
04
2020
revised:
20
05
2020
accepted:
23
05
2020
entrez:
31
5
2020
pubmed:
31
5
2020
medline:
31
5
2020
Statut:
epublish
Résumé
E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a "healthy method" of tobacco consumption. The adverse outcomes of ECS on the respiratory and cardiovascular systems in humans have been recently demonstrated. Nevertheless, the effect of e-cigarette liquid (ECL) on the early stage of embryogenesis and angiogenesis has not been explored yet. Chicken embryo at 3 days of incubation and its chorioallantoic membrane (CAM) of 5 days were used to explore the outcome of ECL on the embryo. Real-time PCR was also employed to study the regulation of a set of key controller genes of embryogenesis as well as angiogenesis. Our study revealed that ECL exposure is associated with a high rate of mortality in embryos as around 70% of treated embryos, at 3 days of incubation, die after 5 days of exposure. Additionally, ECL inhibits angiogenesis of the CAM of 5 days of incubation by more than 30%. These effects could be explained by the upregulation of
Identifiants
pubmed: 32471135
pii: toxics8020038
doi: 10.3390/toxics8020038
pmc: PMC7355589
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Qatar University
ID : QUHI-CMED-19/20-1
Organisme : Qatar University
ID : GCC # 2017-002 QU/KU
Organisme : Qatar University
ID : QUST-1-CMED-2020-2
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