Serum Metabolome Changes in Relation to Prothrombotic State Induced by Combined Oral Contraceptives with Drospirenone and Ethinylestradiol.
Adolescent
Adult
Androstenes
/ administration & dosage
Biomarkers
/ blood
Blood Coagulation
/ drug effects
Blood Platelets
/ drug effects
Contraceptives, Oral, Combined
/ administration & dosage
Erythrocytes
/ drug effects
Ethinyl Estradiol
/ administration & dosage
Female
Gas Chromatography-Mass Spectrometry
Humans
Metabolome
Metabolomics
/ methods
Platelet Activation
/ drug effects
Platelet Aggregation
/ drug effects
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Thrombosis
/ blood
Young Adult
combined oral contraceptives
drospirenone
ethinylestradiol
metabolomics
serum
Journal
Omics : a journal of integrative biology
ISSN: 1557-8100
Titre abrégé: OMICS
Pays: United States
ID NLM: 101131135
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
31
5
2020
medline:
18
5
2021
entrez:
31
5
2020
Statut:
ppublish
Résumé
The association between hypercoagulability and use of drospirenone (DRSP) and ethinylestradiol (EE) containing combined oral contraceptives (COCs) is an important clinical concern. We have previously reported that the two formulations of DRSP combined with EE (namely, DRSP/20EE and DRSP/30EE) bring about a prothrombotic state in hemostatic traits of female users. We report here the serum metabolomic changes in the same study cohort in relation to the attendant prothrombotic state induced by COC use, thus offering new insights on the underlying biochemical mechanisms contributing to the altered coagulatory profile with COC use. A total of 78 healthy women participated in this study and were grouped as follows: control group not using oral contraceptives (
Identifiants
pubmed: 32471328
doi: 10.1089/omi.2020.0009
doi:
Substances chimiques
Androstenes
0
Biomarkers
0
Contraceptives, Oral, Combined
0
Ethinyl Estradiol
423D2T571U
drospirenone
N295J34A25
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM