Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
31
01
2020
accepted:
21
05
2020
pubmed:
31
5
2020
medline:
19
12
2020
entrez:
31
5
2020
Statut:
ppublish
Résumé
Glucose is a primary fuel source to the brain, yet the influence of dysglycemia on neurodevelopment in children with type 1 diabetes remains unclear. We examined brain activation using functional MRI in 80 children with type 1 diabetes (mean ± SD age 11.5 ± 1.8 years; 46% female) and 47 children without diabetes (control group) (age 11.8 ± 1.5 years; 51% female) as they performed a visuospatial working memory (N-back) task. Results indicated that in both groups, activation scaled positively with increasing working memory load across many areas, including the frontoparietal cortex, caudate, and cerebellum. Between groups, children with diabetes exhibited reduced performance on the N-back task relative to children in the control group, as well as greater modulation of activation (i.e., showed greater increase in activation with higher working memory load). Post hoc analyses indicated that greater modulation was associated in the diabetes group with better working memory function and with an earlier age of diagnosis. These findings suggest that increased modulation may occur as a compensatory mechanism, helping in part to preserve working memory ability, and further, that children with an earlier onset require additional compensation. Future studies that test whether these patterns change as a function of improved glycemic control are warranted.
Identifiants
pubmed: 32471809
pii: db20-0123
doi: 10.2337/db20-0123
pmc: PMC7372069
doi:
Banques de données
figshare
['10.2337/figshare.12349781']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1770-1778Subventions
Organisme : NICHD NIH HHS
ID : U10 HD041906
Pays : United States
Organisme : NICHD NIH HHS
ID : U10 HD041918
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NICHD NIH HHS
ID : U10 HD041915
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD078463
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003142
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD087011
Pays : United States
Organisme : NICHD NIH HHS
ID : U10 HD056526
Pays : United States
Organisme : NICHD NIH HHS
ID : U10 HD041908
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK045735
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001085
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000448
Pays : United States
Investigateurs
Eva Tsalikian
(E)
Michael J Tansey
(MJ)
Julie Coffey
(J)
Joanne Cabbage
(J)
Sara Salamat
(S)
Rachel Bisbee
(R)
Nelly Mauras
(N)
Larry A Fox
(LA)
Allison Cato
(A)
Kim Englert
(K)
Kaitlin Sikes
(K)
Tina Ewen
(T)
Keisha Bird
(K)
Bruce A Buckingham
(BA)
Darrell M Wilson
(DM)
Tandy Aye
(T)
Ryan S Kingman
(RS)
Stuart A Weinzimer
(SA)
William V Tamborlane
(WV)
Jodie Ambrosino
(J)
Amy Steffen
(A)
Kate Weyman
(K)
Melinda Zgorski
(M)
Neil H White
(NH)
Ana Maria Arbelaez
(AM)
Lucy Levandoski
(L)
Angie Starnes
(A)
Tamara Hershey
(T)
Allan L Reiss
(AL)
Lara Foland-Ross
(L)
Matthew J Marzelli
(MJ)
Paul K Mazaika
(PK)
Gabby Tong
(G)
Mark Sperling
(M)
Dorothy M Becker
(DM)
Patricia Cleary
(P)
Carla Greenbaum
(C)
Antoinette Moran
(A)
Informations de copyright
© 2020 by the American Diabetes Association.
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