Silencing of CCR4-NOT complex subunits affects heart structure and function.
Action Potentials
Animals
Animals, Genetically Modified
Cell Proliferation
Drosophila Proteins
/ genetics
Drosophila melanogaster
/ genetics
Exoribonucleases
/ genetics
Gene Expression Regulation, Developmental
Gene Silencing
Genome-Wide Association Study
HeLa Cells
Heart Rate
Humans
Induced Pluripotent Stem Cells
/ metabolism
Intracellular Signaling Peptides and Proteins
/ genetics
Long QT Syndrome
/ genetics
Morphogenesis
Myocytes, Cardiac
/ metabolism
RNA-Binding Proteins
/ genetics
Repressor Proteins
/ genetics
Ribonucleases
/ genetics
Transcription Factors
/ genetics
Arrhythmia
CNOT1
Cardiomyocytes
Drosophila heart
GWAS
Long-QT syndrome
hiPSC
Journal
Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332
Informations de publication
Date de publication:
20 07 2020
20 07 2020
Historique:
received:
28
02
2020
accepted:
19
05
2020
pubmed:
31
5
2020
medline:
24
8
2021
entrez:
31
5
2020
Statut:
epublish
Résumé
The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous. Genome-wide association studies have identified variants that associate with QT-interval length (a measure of myocardial repolarization). Three of the strongest associating variants (single-nucleotide polymorphisms) are located in the putative promotor region of
Identifiants
pubmed: 32471864
pii: dmm.044727
doi: 10.1242/dmm.044727
pmc: PMC7390626
pii:
doi:
Substances chimiques
CNOT1 protein, human
0
Cnot4 protein, Drosophila
0
Drosophila Proteins
0
Intracellular Signaling Peptides and Proteins
0
NOT1 protein, Drosophila
0
RNA-Binding Proteins
0
Repressor Proteins
0
Transcription Factors
0
CNOT7 protein, human
EC 3.1.-
Exoribonucleases
EC 3.1.-
Ribonucleases
EC 3.1.-
twin protein, Drosophila
EC 3.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL054732
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124091
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132241
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG061598
Pays : United States
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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