Intraperitoneal injections of copper ferrite nanoparticles disturb blood, plasma, and antioxidant parameters of Wistar rats in a sex-specific manner.
Animals
Antioxidants
/ metabolism
Biomarkers
/ blood
Blood Cell Count
Copper
/ administration & dosage
Female
Ferric Compounds
/ administration & dosage
Injections, Intraperitoneal
Male
Metal Nanoparticles
/ administration & dosage
Oxidative Stress
/ drug effects
Platelet Count
Rats
Rats, Wistar
Sex Characteristics
Antioxidants
Behavior
Blood chemistry
CF NPs
Wistar rat
Journal
Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
01
02
2020
accepted:
06
05
2020
pubmed:
31
5
2020
medline:
10
8
2021
entrez:
31
5
2020
Statut:
ppublish
Résumé
The present study was designed to report the synthesis and characterization of copper ferrite nanoparticles (CF NPs) and their biocompatibility in Wistar rats. Coprecipitation method was used to generate CF NPs having average diameter of 14.06 nm. NPs were characterized by scanning electron microscopy and X-ray diffraction. Six-week-old Wistar rats of both sexes intraperitoneally received 10 mg/ml saline/Kg body weight of CF NPs for 14 days. Control groups were maintained in parallel that received saline solution for 14 days through same route. Open field and novel object recognition tests, complete blood count, selected plasma parameters, antioxidants, and copper concentration in vital organs were determined in all treatments. Female rats treated with CF NPs had significantly higher platelet count (P = 0.05) and platelet crit (P = 0.05) and decreased plasma triglyceride concentration levels (P = 0.02) than control group. Female rats had significantly increased levels of superoxide dismutase (P = 0.01), catalase (P = 0.05), and malonaldehyde (P = 0.05) in the kidney, while male rats had significantly elevated levels of superoxide dismutase in the lungs (P = 0.01) as compared with respective control groups. Copper concentrations in the liver were significantly higher in both female (P = 0.04) and male (P = 0.05) rats exposed to CF NPs than control group. All other studied parameters of behavioral tests, blood biochemistry, antioxidant, and copper concentrations in the brain varied nonsignificantly (P > 0.05) when compared between CF NPs treated and untreated rats of both sexes. Intraperitoneal supplementation of CF NPs for 14 days disturbed the platelet count, plasma triglyceride concentration, copper levels in the liver, and antioxidant concentrations in the kidney of female Wistar rats. These parameters remained unaffected in male subjects.
Identifiants
pubmed: 32472153
doi: 10.1007/s00210-020-01899-x
pii: 10.1007/s00210-020-01899-x
doi:
Substances chimiques
Antioxidants
0
Biomarkers
0
Ferric Compounds
0
ferrite
1317-54-0
Copper
789U1901C5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2019-2028Références
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