SARS-CoV-2 and human milk: What is the evidence?
Adult
Antibodies, Viral
/ analysis
Breast Feeding
COVID-19
/ diagnosis
COVID-19 Testing
Female
Gestational Age
Humans
Immunoglobulin G
/ analysis
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical
/ statistics & numerical data
Male
Milk, Human
/ virology
Pregnancy
Pregnancy Complications, Infectious
/ virology
SARS-CoV-2
/ immunology
COVID-19
SARS-CoV-2
breast milk
breastfeeding
coronavirus
human milk
infectious disease
Journal
Maternal & child nutrition
ISSN: 1740-8709
Titre abrégé: Matern Child Nutr
Pays: England
ID NLM: 101201025
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
07
04
2020
revised:
30
04
2020
accepted:
05
05
2020
pubmed:
31
5
2020
medline:
17
12
2020
entrez:
31
5
2020
Statut:
ppublish
Résumé
The novel coronavirus SARS-CoV-2 has emerged as one of the most compelling and concerning public health challenges of our time. To address the myriad issues generated by this pandemic, an interdisciplinary breadth of research, clinical and public health communities has rapidly engaged to collectively find answers and solutions. One area of active inquiry is understanding the mode(s) of SARS-CoV-2 transmission. Although respiratory droplets are a known mechanism of transmission, other mechanisms are likely. Of particular importance to global health is the possibility of vertical transmission from infected mothers to infants through breastfeeding or consumption of human milk. However, there is limited published literature related to vertical transmission of any human coronaviruses (including SARS-CoV-2) via human milk and/or breastfeeding. Results of the literature search reported here (finalized on 17 April 2020) revealed a single study providing some evidence of vertical transmission of human coronavirus 229E; a single study evaluating presence of SARS-CoV in human milk (it was negative); and no published data on MERS-CoV and human milk. We identified 13 studies reporting human milk tested for SARS-CoV-2; one study (a non-peer-reviewed preprint) detected the virus in one milk sample, and another study detected SARS-CoV-2 specific IgG in milk. Importantly, none of the studies on coronaviruses and human milk report validation of their collection and analytical methods for use in human milk. These reports are evaluated here, and their implications related to the possibility of vertical transmission of coronaviruses (in particular, SARS-CoV-2) during breastfeeding are discussed.
Identifiants
pubmed: 32472745
doi: 10.1111/mcn.13032
pmc: PMC7300480
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13032Subventions
Organisme : NICHD NIH HHS
ID : R01 HD092297
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2020 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.
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