[11C]dihydrotetrabenazine Positron Emission Tomography in Manganese-Exposed Workers.
Journal
Journal of occupational and environmental medicine
ISSN: 1536-5948
Titre abrégé: J Occup Environ Med
Pays: United States
ID NLM: 9504688
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
31
5
2020
medline:
7
8
2021
entrez:
31
5
2020
Statut:
ppublish
Résumé
To understand the neurotoxic effects of manganese (Mn) exposure on monoaminergic function, utilizing [C]dihydrotetrabenazine (DTBZ) positron emission tomography (PET) to measure vesicular monoamine transporter 2 (VMAT2). Basal ganglia and thalamic DTBZ binding potentials (BPND) were calculated on 56 PETs from 41 Mn-exposed workers. Associations between cumulative Mn exposure, regional BPND, and parkinsonism were examined by mixed linear regression. Thalamic DTBZ BPND was inversely associated with exposure in workers with less than 3 mg Mn/m-yrs, but subsequently remained stable. Pallidal DTBZ binding increased in workers with less than 2 mg Mn/m-yrs of exposure, but decreased thereafter. Thalamic DTBZ binding was inversely associated with parkinsonism (P = 0.003). Mn-dose-dependent associations with thalamic and pallidal DTBZ binding indicate direct effects on monoaminergic VMAT2. Thalamic DTBZ binding was also associated with parkinsonism, suggesting potential as an early biomarker of Mn neurotoxicity.
Identifiants
pubmed: 32472844
doi: 10.1097/JOM.0000000000001915
pmc: PMC7786890
mid: NIHMS1647767
pii: 00043764-202010000-00003
doi:
Substances chimiques
Carbon Radioisotopes
0
Carbon-11
0
dihydrotetrabenazine
3466-75-9
Manganese
42Z2K6ZL8P
Tetrabenazine
Z9O08YRN8O
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
788-794Subventions
Organisme : NIEHS NIH HHS
ID : K24 ES017765
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025991
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES026187
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029524
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES026891
Pays : United States
Organisme : NIEHS NIH HHS
ID : K23 ES021444
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES004696
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES026084
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025792
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES021488
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES013743
Pays : United States
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