Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice.
Animals
Bone Marrow
/ metabolism
Cell Line, Tumor
Cell- and Tissue-Based Therapy
Colorectal Neoplasms
/ genetics
Disease Models, Animal
Disease Progression
Gene Expression Regulation, Neoplastic
/ genetics
Heterografts
Humans
Liver Neoplasms
/ genetics
Matrix Metalloproteinase 2
/ genetics
Matrix Metalloproteinase 9
/ genetics
Mice
Myeloid Cells
/ metabolism
Neoplasm Metastasis
Nitric Oxide Synthase Type II
/ genetics
Protein Serine-Threonine Kinases
/ genetics
Vascular Endothelial Growth Factor A
/ genetics
CCR1
Colorectal cancer
Myeloid cell
Tumor microenvironment
Journal
Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
27
03
2020
revised:
12
05
2020
accepted:
20
05
2020
pubmed:
31
5
2020
medline:
13
1
2021
entrez:
31
5
2020
Statut:
ppublish
Résumé
Tumor-stromal interaction is implicated in tumor progression. Although CCR1 expression in myeloid cells could be associated with pro-tumor activity, it remains elusive whether disruption of CCR1-mediated myeloid cell accumulation can suppress tumor progression. Here, we investigated the role of CCR1 depletion in myeloid cells in two syngeneic colorectal cancer mouse models: MC38, a transplanted tumor model and CMT93, a liver metastasis model. Both cells induced tumor accumulation of CCR1
Identifiants
pubmed: 32473241
pii: S0304-3835(20)30290-1
doi: 10.1016/j.canlet.2020.05.028
pii:
doi:
Substances chimiques
Vascular Endothelial Growth Factor A
0
Nitric Oxide Synthase Type II
EC 1.14.13.39
SNF1-related protein kinases
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
Matrix Metalloproteinase 2
EC 3.4.24.24
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
53-62Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest MK is an employee of Kyowa Kirin Co., Ltd. All other authors declare that they have no potential conflicts of interest.