Cystatin C, cognition, and brain MRI findings in 90+-year-olds.
Aging
Brain MRI
Chronic kidney disease
Cognition
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
09
10
2019
revised:
19
04
2020
accepted:
21
04
2020
pubmed:
31
5
2020
medline:
16
1
2021
entrez:
31
5
2020
Statut:
ppublish
Résumé
Chronic kidney disease is emerging as a novel risk factor for cerebrovascular disease, but this association remains largely unexplored in older adults. Cystatin C is a more accurate measure than creatinine of kidney function in the elderly. We evaluated cystatin C, cognitive function, and brain imaging in 193 participants from The 90+ Study neuroimaging component. The mean age was 93.9 years; 61% were women. Mean cystatin C was 1.62 mg/L with estimated glomerular filtration rate 39.2 mL/min/1.73 m
Identifiants
pubmed: 32473464
pii: S0197-4580(20)30142-1
doi: 10.1016/j.neurobiolaging.2020.04.022
pmc: PMC7307913
mid: NIHMS1598044
pii:
doi:
Substances chimiques
Biomarkers
0
Cystatin C
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-84Subventions
Organisme : NIA NIH HHS
ID : P30 AG066519
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016573
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG021055
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS020989
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Références
Transl Stroke Res. 2020 Feb;11(1):122-134
pubmed: 31055735
Age Ageing. 2014 May;43(3):411-7
pubmed: 24321840
Neurology. 2008 Apr 1;70(14):1208-14
pubmed: 18378884
Neuroimage. 2009 Jul 1;46(3):726-38
pubmed: 19245840
Am J Psychiatry. 1986 Oct;143(10):1279-82
pubmed: 3766791
Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1585-92
pubmed: 26209158
N Engl J Med. 2012 Jul 5;367(1):20-9
pubmed: 22762315
Hypertension. 2020 Jan;75(1):237-245
pubmed: 31735081
Transl Stroke Res. 2017 Feb;8(1):67-76
pubmed: 27628245
J Am Soc Nephrol. 2005 May;16(5):1404-12
pubmed: 15788478
Alzheimer Dis Assoc Disord. 2016 Jan-Mar;30(1):21-6
pubmed: 25710250
Front Aging Neurosci. 2017 May 15;9:132
pubmed: 28555103
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
Int Urol Nephrol. 2017 Nov;49(11):1979-1988
pubmed: 28913589
Alzheimer Dis Assoc Disord. 2019 Apr-Jun;33(2):160-162
pubmed: 29734262
J Cereb Blood Flow Metab. 2019 Oct;39(10):1893-1905
pubmed: 31366298
Neuropsychology. 2018 May;32(4):436-449
pubmed: 29494196
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Am J Kidney Dis. 2001 Jan;37(1):79-83
pubmed: 11136171
Neurobiol Aging. 2017 Aug;56:108-114
pubmed: 28527525
J Gerontol. 1982 May;37(3):323-9
pubmed: 7069156
Arch Gerontol Geriatr. 1999 Jul-Aug;29(1):75-94
pubmed: 15374079
Neuropharmacology. 2018 May 15;134(Pt B):226-239
pubmed: 29273521
Neurology. 2013 Jan 29;80(5):471-80
pubmed: 23303848
JAMA Netw Open. 2019 May 3;2(5):e193359
pubmed: 31074810
Ann Neurol. 2008 Jun;63(6):798-802
pubmed: 18496846
Stroke. 2017 Nov;48(11):2964-2972
pubmed: 29018129
Int Psychogeriatr. 1994 Spring;6(1):45-58; discussion 62
pubmed: 8054493
J Alzheimers Dis. 2015;44(1):319-28
pubmed: 25213770
Neurology. 2008 Jul 29;71(5):337-43
pubmed: 18596243
Am J Hypertens. 2012 Apr;25(4):430-6
pubmed: 22237153
J Clin Exp Neuropsychol. 2007 Apr;29(3):290-9
pubmed: 17454349
Ageing Res Rev. 2016 Dec;32:38-50
pubmed: 27333827
J Am Soc Nephrol. 2005 Jul;16(7):2127-33
pubmed: 15888561
J Chronic Dis. 1986;39(9):699-707
pubmed: 3734024
Neurology. 2009 Nov 24;73(21):1759-66
pubmed: 19933977
Am J Kidney Dis. 2002 Aug;40(2):221-6
pubmed: 12148093
Am J Epidemiol. 2014 Jul 1;180(1):68-75
pubmed: 24844846
J Am Soc Nephrol. 2004 Jul;15(7):1904-11
pubmed: 15213280
Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5319-22
pubmed: 23367130
J Am Geriatr Soc. 2004 Nov;52(11):1863-9
pubmed: 15507063
Arch Neurol. 2000 Nov;57(11):1579-83
pubmed: 11074789