Effect of add-on transcranial alternating current stimulation (tACS) on persistent delusions in schizophrenia.
Alpha-tACS
Delusions
Treatment-resistant schizophrenia
Journal
Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
17
03
2020
revised:
14
05
2020
accepted:
14
05
2020
pubmed:
1
6
2020
medline:
15
12
2020
entrez:
1
6
2020
Statut:
ppublish
Résumé
The utility of non-invasive brain stimulation techniques to alleviate resistant delusions in schizophrenia is an under-researched area. In this study, we report the effectiveness of alpha transcranial alternating current stimulation (tACS) targeting the medial prefrontal cortex in ameliorating persistent delusions. Twelve Schizophrenia patients (N=12) with persistent delusions received add-on treatment with a twice-daily 20-minutes session of 10-Hz tACS. Significant reduction in severity of delusion was noted after 5th day (z=2.67, p<0.01, n=12) with further improvement after 10th day (z=2.52, p=0.01, n=9) of stimulation. Add-on treatment with 10-Hz tACS is a potential therapeutic option for treatment-resistant delusions, which requires further systematic research.
Identifiants
pubmed: 32474070
pii: S0165-1781(20)30575-8
doi: 10.1016/j.psychres.2020.113106
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113106Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest There are no potential conflicts of interest to report for any of the authors.