GABA
GABA(A) receptor
benzodiazepine
drug history
remifentanil
rhesus monkey
self-administration
Journal
Drug and alcohol dependence
ISSN: 1879-0046
Titre abrégé: Drug Alcohol Depend
Pays: Ireland
ID NLM: 7513587
Informations de publication
Date de publication:
01 Aug 2020
01 Aug 2020
Historique:
received:
17
12
2019
revised:
12
05
2020
accepted:
13
05
2020
medline:
1
6
2020
pubmed:
1
6
2020
entrez:
1
6
2020
Statut:
ppublish
Résumé
Opioid-use disorder is associated with a high degree of co-abuse with benzodiazepines. While the mechanisms underlying the co-abuse of opioids and benzodiazepines remain unknown, α1 subunit-containing GABA The reinforcing effects of L-838,417 (partial intrinsic efficacy at α2, α3, and α5 subunit-containing GABA Neither the partial modulator nor the α1-sparing compound were self-administered above vehicle levels. The full modulators triazolam and lorazepam were self-administered significantly above vehicle levels, albeit at lower levels than remifentanil. Our findings suggest that relatively high efficacy at one or more GABA
Sections du résumé
BACKGROUND
BACKGROUND
Opioid-use disorder is associated with a high degree of co-abuse with benzodiazepines. While the mechanisms underlying the co-abuse of opioids and benzodiazepines remain unknown, α1 subunit-containing GABA
METHODS
METHODS
The reinforcing effects of L-838,417 (partial intrinsic efficacy at α2, α3, and α5 subunit-containing GABA
RESULTS
RESULTS
Neither the partial modulator nor the α1-sparing compound were self-administered above vehicle levels. The full modulators triazolam and lorazepam were self-administered significantly above vehicle levels, albeit at lower levels than remifentanil.
CONCLUSIONS
CONCLUSIONS
Our findings suggest that relatively high efficacy at one or more GABA
Identifiants
pubmed: 32474260
pii: S0376-8716(20)30241-6
doi: 10.1016/j.drugalcdep.2020.108076
pmc: PMC7371532
mid: NIHMS1598394
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108076Subventions
Organisme : NIDA NIH HHS
ID : R01 DA011792
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA043204
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.