Increased anxiety-related behavior in mice following β-citronellol inhalation.
Anxiogenic
citronellol
essential oil
inhalation
odor
Journal
The Libyan journal of medicine
ISSN: 1819-6357
Titre abrégé: Libyan J Med
Pays: United States
ID NLM: 101299403
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
13
7
2021
Statut:
ppublish
Résumé
β-Citronellol is a monoterpene alcohol found in essential oils of various aromatic plant species. The physiological effects of β-citronellol inhalation on the central nervous system remain unclear. We investigated the effects of β-citronellol inhalation on mouse behavior. First, we examined whether the odor of β-citronellol was attractive or repellent to mice. Then, following 30 minutes of β-citronellol inhalation, a series of behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, and forced swim tests) were performed. Mice were neither attracted to nor repelled by β-citronellol. Mice that inhaled β-citronellol showed an increase in anxiety-like behavior in the elevated plus maze and open field tests. Performance in the Y-maze and forced swim tests was not affected. These results indicate that β-citronellol acts on the central nervous system of mice following inhalation and increases anxiety. Essential oils and cosmetics containing β-citronellol should be used with caution.
Identifiants
pubmed: 32475228
doi: 10.1080/19932820.2020.1767275
pmc: PMC7646537
doi:
Substances chimiques
Monoterpenes
0
Oils, Volatile
0
beta-citronellene
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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