Use of hyperglycemic clamp to assess pancreatectomy and islet cell autotransplant in patient with heterotaxy syndrome and dorsal pancreas agenesis leading to chronic pancreatitis.
anatomy
autotransplantation
clinical research/practice
diabetes
endocrinology/diabetology
islet isolation
islet transplantation
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
26
03
2020
revised:
28
04
2020
accepted:
15
05
2020
pubmed:
2
6
2020
medline:
22
6
2021
entrez:
2
6
2020
Statut:
ppublish
Résumé
Patients with heterotaxy syndrome (HS) can present with an associated complete dorsal pancreas agenesis (DPA). They are considered to be at increased risk for developing diabetes due to a reduced functional beta cell mass (FBM) as well as for chronic pancreatitis leading to unmanageable pain. We report the case of a young woman with chronic pancreatitis due to HS and associated DPA. She presented with a severe persisting upper abdominal pain refractory to nonsurgical treatment. Unlike in previously reported cases, she had a high FBM (ie, 150% of normoglycemic controls) as determined by hyperglycemic clamp. She underwent a total pancreatectomy followed within 24 hours by an intraportal autologous islet cell transplant containing 4 × 10
Identifiants
pubmed: 32476268
doi: 10.1111/ajt.16084
pii: S1600-6135(22)21648-7
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
3662-3666Informations de copyright
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.
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