Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting.
Astrocytes
dogs
hepatic encephalopathy
portosystemic
Journal
Journal of veterinary science
ISSN: 1976-555X
Titre abrégé: J Vet Sci
Pays: Korea (South)
ID NLM: 100964185
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
05
11
2019
revised:
18
03
2020
accepted:
23
03
2020
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
21
10
2020
Statut:
ppublish
Résumé
Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is a major cause of morbidity and mortality. Despite HE been a major cause of morbidity in dogs with a cPSS, little is known about the cellular changes that occur in the central nervous system of dogs with a cPSS. The objective of this study was to characterise the histological changes in the cerebral cortex and cerebellum of dogs with cPSS with particular emphasis on astrocyte morphology. Eight dogs with a confirmed cPSS were included in the study. Six dogs had substantial numbers of Alzheimer type II astrocytes and all cases had increased immunoreactivity for glial fibrillary acidic protein in the cerebral cortex, even if there were minimal other morphological changes. This study demonstrates that dogs with a cPSS have marked cellular changes in the cerebral cortex and cerebellum. The cellular changes that occur in the cerebral cortex and cerebellum of dogs with spontaneously arising HE are similar to changes which occur in humans with HE, further validating dogs with a cPSS as a good model for human HE.
Sections du résumé
BACKGROUND
BACKGROUND
Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is a major cause of morbidity and mortality. Despite HE been a major cause of morbidity in dogs with a cPSS, little is known about the cellular changes that occur in the central nervous system of dogs with a cPSS.
OBJECTIVES
OBJECTIVE
The objective of this study was to characterise the histological changes in the cerebral cortex and cerebellum of dogs with cPSS with particular emphasis on astrocyte morphology.
METHODS
METHODS
Eight dogs with a confirmed cPSS were included in the study.
RESULTS
RESULTS
Six dogs had substantial numbers of Alzheimer type II astrocytes and all cases had increased immunoreactivity for glial fibrillary acidic protein in the cerebral cortex, even if there were minimal other morphological changes.
CONCLUSIONS
CONCLUSIONS
This study demonstrates that dogs with a cPSS have marked cellular changes in the cerebral cortex and cerebellum. The cellular changes that occur in the cerebral cortex and cerebellum of dogs with spontaneously arising HE are similar to changes which occur in humans with HE, further validating dogs with a cPSS as a good model for human HE.
Identifiants
pubmed: 32476318
pii: 21.e44
doi: 10.4142/jvs.2020.21.e44
pmc: PMC7263922
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e44Informations de copyright
© 2020 The Korean Society of Veterinary Science.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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