Everyday cognitive failure in patients suffering from neurosarcoidosis.
Adult
Aged
Attention
Case-Control Studies
Central Nervous System Diseases
/ diagnosis
Cognition
Cognitive Dysfunction
/ diagnosis
Cross-Sectional Studies
Fatigue
/ epidemiology
Female
Humans
Male
Memory
Memory Disorders
/ diagnosis
Middle Aged
Netherlands
/ epidemiology
Prevalence
Prognosis
Risk Factors
Sarcoidosis
/ diagnosis
Small Fiber Neuropathy
/ epidemiology
Young Adult
cognitive failure
fatigue
neurosarcoidosis
sarcoidosis
small fiber neuropathy (SFN)
Journal
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
ISSN: 2532-179X
Titre abrégé: Sarcoidosis Vasc Diffuse Lung Dis
Pays: Italy
ID NLM: 9610928
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
05
2018
accepted:
14
11
2018
entrez:
2
6
2020
pubmed:
1
1
2019
medline:
1
7
2020
Statut:
ppublish
Résumé
Cognitive failure is associated with memory and concentration problems. Previously, a prevalence of one third was found in a general sarcoidosis population. The aim of this study was to assess if neurosarcoidosis patients are at higher risk for developing everyday cognitive failure using the Cognitive Failure Questionnaire (CFQ) and to determine what factors were associated with cognitive failure. A cross-sectional web-based survey was conducted from April to May 2017 in a national sample of neurosarcoidosis patients. The survey asked about complaints and included 3 questionnaires (Fatigue Assessment Scale [FAS], Small Fiber Neuropathy Screening List [SFNSL] and CFQ. Data were compared to a general sarcoidosis population. Of the 152 patients who completed the survey, 131 had neurosarcoidosis. The mean CFQ score was significantly higher in the neurosarcoidosis (45.6±20.7) compared to the general sarcoidosis population (36.2±15.9; p< 0.0001). High CFQ scores (≥43) were found in 55.7% and 33.9%, respectively (p<0.0001). The FAS score (OR 21.4) and SFNSL score (OR 4.3) were the strongest positive predictors of a high CFQ score. Cognitive failure is a significant problem in neurosarcoidosis. More than half of the patients reported cognitive deficits, compared to one third of a general sarcoidosis population. Fatigue and small fiber neuropathy play a role in cognitive failure.
Sections du résumé
BACKGROUND
BACKGROUND
Cognitive failure is associated with memory and concentration problems. Previously, a prevalence of one third was found in a general sarcoidosis population. The aim of this study was to assess if neurosarcoidosis patients are at higher risk for developing everyday cognitive failure using the Cognitive Failure Questionnaire (CFQ) and to determine what factors were associated with cognitive failure.
METHODS
METHODS
A cross-sectional web-based survey was conducted from April to May 2017 in a national sample of neurosarcoidosis patients. The survey asked about complaints and included 3 questionnaires (Fatigue Assessment Scale [FAS], Small Fiber Neuropathy Screening List [SFNSL] and CFQ. Data were compared to a general sarcoidosis population.
RESULTS
RESULTS
Of the 152 patients who completed the survey, 131 had neurosarcoidosis. The mean CFQ score was significantly higher in the neurosarcoidosis (45.6±20.7) compared to the general sarcoidosis population (36.2±15.9; p< 0.0001). High CFQ scores (≥43) were found in 55.7% and 33.9%, respectively (p<0.0001). The FAS score (OR 21.4) and SFNSL score (OR 4.3) were the strongest positive predictors of a high CFQ score.
CONCLUSION
CONCLUSIONS
Cognitive failure is a significant problem in neurosarcoidosis. More than half of the patients reported cognitive deficits, compared to one third of a general sarcoidosis population. Fatigue and small fiber neuropathy play a role in cognitive failure.
Identifiants
pubmed: 32476930
doi: 10.36141/svdld.v36i1.7412
pii: SVDLD-36-2
pmc: PMC7247119
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2-10Informations de copyright
Copyright: © 2019.
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