Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man.
KCa2
SK channels
anti-arrhythmic drugs
atrial fibrillation
ion channels
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
12
2019
accepted:
20
04
2020
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
2
6
2020
Statut:
epublish
Résumé
Small conductance Ca Whole-cell and inside-out patch-clamp recordings of heterologously expressed K AP30663 is a novel negative allosteric modulator of K
Identifiants
pubmed: 32477117
doi: 10.3389/fphar.2020.00610
pmc: PMC7232560
doi:
Types de publication
Journal Article
Langues
eng
Pagination
610Informations de copyright
Copyright © 2020 Bentzen, Bomholtz, Simó-Vicens, Folkersen, Abildgaard, Speerschneider, Muthukumarasamy, Edvardsson, Sørensen, Grunnet and Diness.
Références
Br J Pharmacol. 2017 Dec;174(23):4396-4408
pubmed: 28925012
Cardiovasc Res. 2014 Jul 1;103(1):156-67
pubmed: 24817686
Heart Rhythm. 2015 Apr;12(4):825-35
pubmed: 25542425
Eur Heart J. 2016 Oct 7;37(38):2893-2962
pubmed: 27567408
Circ Arrhythm Electrophysiol. 2010 Aug;3(4):380-90
pubmed: 20562443
Am J Cardiol. 2011 Sep 1;108(5):673-6
pubmed: 21726841
Circulation. 2007 Oct 9;116(15):1647-52
pubmed: 17804441
Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):348-59
pubmed: 18855648
J Am Coll Cardiol. 2010 Feb 23;55(8):801-9
pubmed: 20170820
Cardiovasc Res. 2014 Feb 1;101(2):317-25
pubmed: 24282291
Cardiovasc Drugs Ther. 2013 Feb;27(1):79-89
pubmed: 23108433
J Physiol. 1984 Dec;357:127-49
pubmed: 6150992
Circulation. 2014 Jan 28;129(4):430-40
pubmed: 24190961
Nat Genet. 2010 Mar;42(3):240-4
pubmed: 20173747
Heart Rhythm. 2011 Aug;8(8):1281-90
pubmed: 21421082
Front Pharmacol. 2019 Jun 19;10:668
pubmed: 31275147
Nat Genet. 2012 Apr 29;44(6):670-5
pubmed: 22544366
Circulation. 1998 Dec 8;98(23):2545-52
pubmed: 9843461
J Mol Cell Cardiol. 2014 Sep;74:220-30
pubmed: 24877995
J Cardiovasc Pharmacol Ther. 2004 Sep;9 Suppl 1:S65-83
pubmed: 15378132
J Physiol. 2009 Mar 1;587(Pt 5):1087-100
pubmed: 19139040
J Pharmacol Exp Ther. 2004 Aug;310(2):599-605
pubmed: 15031300
PLoS One. 2015 Jun 29;10(6):e0131432
pubmed: 26121051
Mol Pharmacol. 2006 Nov;70(5):1771-82
pubmed: 16926279
Circ Arrhythm Electrophysiol. 2017 Oct;10(10):
pubmed: 29018167
J Physiol. 2017 Jun 15;595(12):3847-3865
pubmed: 28346695
Circ Arrhythm Electrophysiol. 2017 Oct;10(10):
pubmed: 29018164
Circ Res. 2008 Feb 29;102(4):465-71
pubmed: 18096820
J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):61-101
pubmed: 23689033
Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2714-23
pubmed: 16055520
Nat Genet. 2017 Jun;49(6):946-952
pubmed: 28416818
J Physiol. 2018 Sep;596(18):4299-4322
pubmed: 29917243
Hypertension. 2011 Jun;57(6):1129-35
pubmed: 21502564
Biopreserv Biobank. 2015 Oct;13(5):311-9
pubmed: 26484571
J Cardiovasc Pharmacol Ther. 2017 Jan;22(1):3-19
pubmed: 27260643
Mol Med. 2011;17(11-12):1365-73
pubmed: 21968790