Deciphering Natural Killer Cell Homeostasis.
Animals
Cell Differentiation
/ genetics
Cell Plasticity
/ immunology
Cell Proliferation
Cell- and Tissue-Based Therapy
/ methods
Homeostasis
/ immunology
Humans
Interleukin-15
/ metabolism
Killer Cells, Natural
/ immunology
Lymphocyte Activation
Mice
Neoplasms
/ therapy
TOR Serine-Threonine Kinases
/ metabolism
Transcription, Genetic
IL-15
NK cell differentiation
homeostasis
mTOR
natural killer cells (NK cells)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
01
2020
accepted:
08
04
2020
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
1
4
2021
Statut:
epublish
Résumé
Natural killer (NK) cells have a central role within the innate immune system, eliminating virally infected, foreign and transformed cells through their natural cytotoxic capacity. Release of their cytotoxic granules is tightly controlled through the balance of a large repertoire of inhibitory and activating receptors, and it is the unique combination of these receptors expressed by individual cells that confers immense diversity both in phenotype and functionality. The diverse, yet unique, NK cell repertoire within an individual is surprisingly stable over time considering the constant renewal of these cells at steady state. Here we give an overview of NK cell differentiation and discuss metabolic requirements, intra-lineage plasticity and transcriptional reprogramming during IL-15-driven homeostatic proliferation. New insights into the regulation of NK cell differentiation and homeostasis could pave the way for the successful implementation of NK cell-based immunotherapy against cancer.
Identifiants
pubmed: 32477340
doi: 10.3389/fimmu.2020.00812
pmc: PMC7235169
doi:
Substances chimiques
Interleukin-15
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
812Informations de copyright
Copyright © 2020 Pfefferle, Jacobs, Haroun-Izquierdo, Kveberg, Sohlberg and Malmberg.
Références
Nat Rev Immunol. 2014 Mar;14(3):154-65
pubmed: 24481337
Science. 2018 Jun 15;360(6394):
pubmed: 29903938
Oncotarget. 2015 Sep 15;6(27):23058-134
pubmed: 26405162
J Immunol. 2016 Mar 15;196(6):2552-60
pubmed: 26873994
Immunity. 2001 Nov;15(5):751-61
pubmed: 11728337
Blood. 1992 Jun 15;79(12):3239-44
pubmed: 1375847
Nature. 2018 Aug;560(7719):494-498
pubmed: 30089906
J Exp Med. 2010 Sep 27;207(10):2065-72
pubmed: 20819928
Biol Blood Marrow Transplant. 2014 Jun;20(6):896-9
pubmed: 24631739
Nature. 1999 Feb 25;397(6721):702-6
pubmed: 10067894
Nat Commun. 2014 Oct 30;5:5108
pubmed: 25355530
J Leukoc Biol. 2016 Jun;99(6):1065-76
pubmed: 26710799
J Immunol. 2008 Aug 1;181(3):2227-37
pubmed: 18641363
Blood. 2018 Mar 8;131(10):1053-1062
pubmed: 29358179
J Exp Med. 2000 Aug 7;192(3):325-36
pubmed: 10934221
J Clin Oncol. 2015 Jan 1;33(1):74-82
pubmed: 25403209
J Immunol Res. 2018 Apr 15;2018:1586905
pubmed: 29850617
PLoS One. 2012;7(1):e30264
pubmed: 22279576
J Exp Med. 2014 Apr 7;211(4):635-42
pubmed: 24663216
J Immunol. 2011 May 15;186(10):5729-37
pubmed: 21451108
Immunity. 2015 Aug 18;43(2):394-407
pubmed: 26287684
Biol Blood Marrow Transplant. 2019 Nov;25(11):2143-2151
pubmed: 31271885
J Exp Med. 2010 Sep 27;207(10):2073-9
pubmed: 20819924
Cancer Immunol Immunother. 2019 Aug;68(8):1379-1389
pubmed: 31338557
J Exp Med. 2017 Feb;214(2):491-510
pubmed: 28057804
Curr Opin Immunol. 2017 Jun;46:82-88
pubmed: 28521236
Nat Immunol. 2006 May;7(5):507-16
pubmed: 16617337
EMBO J. 2014 Nov 18;33(22):2721-34
pubmed: 25319415
Immunol Rev. 2006 Dec;214:56-72
pubmed: 17100876
PLoS One. 2010 Aug 06;5(8):e11966
pubmed: 20700504
Eur J Immunol. 2009 Aug;39(8):2088-94
pubmed: 19637200
J Exp Med. 2007 Jul 9;204(7):1665-75
pubmed: 17591857
Blood. 2001 Aug 1;98(3):877-9
pubmed: 11468191
Clin Cancer Res. 2016 Apr 15;22(8):1914-21
pubmed: 26787753
Nat Rev Drug Discov. 2020 Mar;19(3):200-218
pubmed: 31907401
J Exp Med. 1994 Aug 1;180(2):569-76
pubmed: 7519241
Nat Commun. 2019 Jan 31;10(1):514
pubmed: 30705279
Lancet Haematol. 2019 Aug;6(8):e409-e418
pubmed: 31248843
Immunity. 2018 Jun 19;48(6):1104-1117
pubmed: 29924976
Nat Immunol. 2007 Aug;8(8):856-63
pubmed: 17618288
Front Immunol. 2018 Mar 19;9:547
pubmed: 29616038
Immunity. 2018 Nov 20;49(5):971-986.e5
pubmed: 30413361
Blood Adv. 2019 Jul 9;3(13):1970-1980
pubmed: 31266741
Sci Transl Med. 2013 Oct 23;5(208):208ra145
pubmed: 24154599
Nat Immunol. 2005 Dec;6(12):1236-44
pubmed: 16273099
Blood. 2004 Dec 1;104(12):3664-71
pubmed: 15304389
Blood. 2012 Jan 12;119(2):399-410
pubmed: 22096237
Science. 2011 Nov 4;334(6056):678-83
pubmed: 22053050
J Biol Chem. 2002 Apr 5;277(14):12246-52
pubmed: 11788581
Nat Immunol. 2014 Aug;15(8):749-757
pubmed: 24973821
Oncoimmunology. 2016 Apr 25;5(6):e1163462
pubmed: 27471638
EMBO Rep. 2016 Feb;17(2):266-78
pubmed: 26682800
J Immunol. 1997 Jul 15;159(2):694-702
pubmed: 9218584
Cell Rep. 2019 Nov 19;29(8):2284-2294.e4
pubmed: 31747601
N Engl J Med. 2020 Feb 6;382(6):545-553
pubmed: 32023374
Trends Immunol. 2014 Aug;35(8):358-67
pubmed: 25047416
Nature. 1995 Sep 7;377(6544):65-8
pubmed: 7659163
Cancer Res. 2013 Mar 15;73(6):1777-86
pubmed: 23302231
Nature. 2006 Mar 23;440(7083):540-4
pubmed: 16525420
Science. 2002 Mar 15;295(5562):2097-100
pubmed: 11896281
Biol Blood Marrow Transplant. 2008 Jul;14(7):807-16
pubmed: 18541201
JCI Insight. 2018 Feb 8;3(3):
pubmed: 29415897
J Immunol. 2008 Nov 1;181(9):5817-27
pubmed: 18941169
Blood. 1996 Apr 1;87(7):2632-40
pubmed: 8639878
J Exp Med. 2009 Dec 21;206(13):2977-86
pubmed: 19995955
Blood. 2009 Mar 12;113(11):2434-41
pubmed: 18974374
Cell. 2019 Jan 10;176(1-2):348-360.e12
pubmed: 30595449
Nat Immunol. 2014 Jun;15(6):546-53
pubmed: 24747678
J Exp Med. 2006 Apr 17;203(4):1033-43
pubmed: 16606675
Nat Immunol. 2004 Dec;5(12):1260-5
pubmed: 15531883
Mol Oncol. 2015 Dec;9(10):1904-17
pubmed: 26604011
Front Immunol. 2014 Apr 23;5:187
pubmed: 24795729
FEBS J. 2018 Feb;285(3):416-431
pubmed: 28755482
Nat Immunol. 2016 Jun;17(6):704-11
pubmed: 27064374
Blood. 2013 Apr 4;121(14):2678-88
pubmed: 23325834
Nature. 2016 Apr 21;532(7599):389-93
pubmed: 27064903
Immunol Rev. 1997 Feb;155:41-52
pubmed: 9059881
Trends Immunol. 2001 Nov;22(11):633-40
pubmed: 11698225
Nat Immunol. 2009 Oct;10(10):1118-24
pubmed: 19749763
Front Immunol. 2019 May 31;10:1205
pubmed: 31214177
Front Immunol. 2016 Jun 20;7:241
pubmed: 27379101
J Exp Med. 2007 May 14;204(5):1119-30
pubmed: 17452521
Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10332-6
pubmed: 1946452
Nat Rev Immunol. 2003 May;3(5):413-25
pubmed: 12766763
Blood. 2005 Jul 1;106(1):376-83
pubmed: 15755898
Nat Immunol. 2016 Jul;17(7):816-24
pubmed: 27213690
Curr Opin Immunol. 2016 Apr;39:143-9
pubmed: 26945468
Blood. 2012 Mar 15;119(11):2665-74
pubmed: 22180440
Blood. 2011 May 12;117(19):5152-6
pubmed: 21415265
Immunity. 1997 Dec;7(6):753-63
pubmed: 9430221
Cell. 2016 Jun 30;166(1):63-76
pubmed: 27293185
Leukemia. 2018 Feb;32(2):520-531
pubmed: 28725044
J Immunother Cancer. 2019 Mar 21;7(1):82
pubmed: 30898149
J Immunol. 2011 Jun 15;186(12):6753-61
pubmed: 21555534
Immunol Rev. 2008 Aug;224:85-97
pubmed: 18759922
Semin Immunol. 2014 Apr;26(2):132-7
pubmed: 24661538
Blood. 2009 Jul 2;114(1):95-104
pubmed: 19304956
Front Immunol. 2017 Apr 24;8:454
pubmed: 28484454
J Immunol. 2011 Mar 15;186(6):3299-303
pubmed: 21317389
Blood. 2013 Apr 4;121(14):2669-77
pubmed: 23365458
J Exp Med. 2000 Aug 21;192(4):557-64
pubmed: 10952725
Immunity. 2006 Aug;25(2):331-42
pubmed: 16901727
Eur J Immunol. 1992 Jan;22(1):1-6
pubmed: 1370410
Genes Immun. 2007 Apr;8(3):245-53
pubmed: 17315044
Clin Cancer Res. 2018 Apr 15;24(8):1834-1844
pubmed: 29444931
Blood. 2018 Jun 7;131(23):2515-2527
pubmed: 29463563
Trends Immunol. 2009 Apr;30(4):143-9
pubmed: 19282243
Immunity. 2015 Mar 17;42(3):443-56
pubmed: 25786176
J Exp Med. 2014 Jun 30;211(7):1289-96
pubmed: 24958849
Blood. 2010 Nov 11;116(19):3865-74
pubmed: 20733159
Front Immunol. 2019 Sep 11;10:2140
pubmed: 31572366
Cell. 2014 Aug 28;158(5):1022-1032
pubmed: 25171404
Blood. 2001 May 15;97(10):3146-51
pubmed: 11342442
Cell Rep. 2018 Jan 23;22(4):860-868
pubmed: 29420173
J Exp Med. 2009 Jan 16;206(1):25-34
pubmed: 19103877
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14725-32
pubmed: 21825173
Nat Rev Immunol. 2011 Sep 23;11(10):658-71
pubmed: 21941294
Nat Rev Immunol. 2016 Apr 28;16(5):310-20
pubmed: 27121652
Front Immunol. 2013 Dec 09;4:422
pubmed: 24367364
Blood. 2005 Apr 15;105(8):3051-7
pubmed: 15632206
Nature. 2009 Jan 29;457(7229):557-61
pubmed: 19136945
J Immunol. 2011 Apr 15;186(8):4590-8
pubmed: 21402893
J Immunol. 2019 Feb 1;202(3):736-746
pubmed: 30578306
Immunity. 2015 Aug 18;43(2):331-42
pubmed: 26253785
Nature. 2017 Dec 21;552(7685):404-409
pubmed: 29236683
Clin Cancer Res. 2018 Nov 15;24(22):5552-5561
pubmed: 30045932
Blood. 2010 Nov 11;116(19):3853-64
pubmed: 20696944
Blood. 2009 Nov 5;114(19):4117-27
pubmed: 19704116
Cell Mol Immunol. 2013 May;10(3):230-52
pubmed: 23604045
Immunity. 2012 Jan 27;36(1):55-67
pubmed: 22261438
Elife. 2017 Sep 06;6:
pubmed: 28875936
Nat Immunol. 2017 Sep;18(9):1004-1015
pubmed: 28759001
J Immunol. 2013 Nov 15;191(10):4989-95
pubmed: 24108698
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15035-40
pubmed: 14657380
Front Immunol. 2016 Apr 15;7:144
pubmed: 27148263
Nat Rev Immunol. 2015 Sep 15;15(9):574-84
pubmed: 26272293
J Immunol. 2007 Apr 15;178(8):4947-55
pubmed: 17404276
Blood. 2014 Oct 16;124(16):2533-43
pubmed: 25205117
Cell Stem Cell. 2018 Aug 02;23(2):181-192.e5
pubmed: 30082067
EMBO J. 1998 Jan 15;17(2):384-95
pubmed: 9430630
Nat Genet. 2000 Jun;25(2):173-6
pubmed: 10835631
J Clin Invest. 2012 Mar;122(3):821-32
pubmed: 22354167
Int Immunol. 2011 Jul;23(7):427-31
pubmed: 21665959
Blood. 2016 Sep 15;128(11):1475-89
pubmed: 27465917
Immunol Rev. 2015 Sep;267(1):197-213
pubmed: 26284479
Front Immunol. 2016 Oct 06;7:402
pubmed: 27766097
J Immunol. 2014 Nov 1;193(9):4477-84
pubmed: 25261477
PLoS Comput Biol. 2013;9(9):e1003222
pubmed: 24068905
Blood. 2005 Jun 1;105(11):4416-23
pubmed: 15728129
Immunogenetics. 2017 Aug;69(8-9):547-556
pubmed: 28699110