Postnatal Involution and Counter-Involution of the Thymus.
Myc
aging
cyclin D1
growth
involution
thymus
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
02
2020
accepted:
17
04
2020
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc in thymic epithelial cells (TEC)s results in considerable increase in thymus size. These models provide useful experimental tools that allow thymus function to be understood. In future, understanding TEC-specific controllers of growth will provide new approaches to thymus regeneration.
Identifiants
pubmed: 32477366
doi: 10.3389/fimmu.2020.00897
pmc: PMC7235445
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
897Informations de copyright
Copyright © 2020 Cowan, Takahama, Bhandoola and Ohigashi.
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