Role of sodium-glucose co-transporter-2 inhibitors in the management of heart failure in patients with diabetes mellitus.
Canagliflozin
Dapagliflozin
Empagliflozin
Heart failure
Sodium-glucose co-transporter-2 inhibitors
Type 2 diabetes mellitus
Journal
World journal of diabetes
ISSN: 1948-9358
Titre abrégé: World J Diabetes
Pays: United States
ID NLM: 101547524
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
04
01
2020
revised:
29
02
2020
accepted:
04
04
2020
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
2
6
2020
Statut:
ppublish
Résumé
Heart failure (HF) is a major complication of diabetes mellitus (DM). Patients with DM have considerably higher risk for HF than non-diabetic subjects and HF is also more severe in the former. Given the rising prevalence of DM, the management of HF in diabetic patients has become the focus of increased attention. In this context, the findings of several randomized, placebo-controlled trials that evaluated the effects of sodium-glucose co-transporter-2 inhibitors on the risk of hospitalization for HF in patients with type 2 DM represent a paradigm shift in the management of HF. These agents consistently reduced the risk of hospitalization for HF both in patients with and in those without HF. These benefits appear to be partly independent from glucose-lowering and have also been reported in patients without DM. However, there are more limited data regarding the benefit of sodium-glucose co-transporter-2 inhibitors in patients with HF and preserved left ventricular ejection fraction, which is the commonest type of HF in diabetic patients.
Identifiants
pubmed: 32477451
doi: 10.4239/wjd.v11.i5.150
pmc: PMC7243487
doi:
Types de publication
Editorial
Langues
eng
Pagination
150-154Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: All authors declare no conflict of interest related to this publication.
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