Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism.
apolipoprotein A-I
cancer
cholesterol
de novo serine synthesis pathway
mevalonate pathway
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
12 May 2020
12 May 2020
Historique:
received:
07
12
2019
accepted:
10
04
2020
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
2
6
2020
Statut:
epublish
Résumé
Previously, we reported apolipoprotein A-I (apoA-I), the major protein component of high-density lipoprotein (HDL), has potent anti-melanoma activity. We used DNA microarray and bioinformatics to interrogate gene expression profiles of tumors from apoA-I expressing (A-I Tg
Identifiants
pubmed: 32477466
doi: 10.18632/oncotarget.27590
pii: 27590
pmc: PMC7233810
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1777-1796Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL076491
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128300
Pays : United States
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST Dr. Hazen reports being named as co-inventor on pending and issued patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics. Dr. Hazen also reports being a paid consultant for P&G, having received research funds from P&G and Roche Diagnostics, and being eligible to receive royalty payments for inventions or discoveries related to cardiovascular diagnostics or therapeutics from Cleveland HeartLab and P&G. All remaining authors declare that they have no conflicts of interest with the contents of this article.
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