Developing a Search Engine for Precision Medicine.
Journal
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
ISSN: 2153-4063
Titre abrégé: AMIA Jt Summits Transl Sci Proc
Pays: United States
ID NLM: 101539486
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
2
6
2020
Statut:
epublish
Résumé
Precision medicine focuses on developing new treatments based on an individual's genetic, environmental, and lifestyle profile. While this data-driven approach has led to significant advances, retrieving information specific to a patient's condition has proved challenging for oncologists due to the large volume of data. In this paper, we propose the PRecIsion Medicine Robust Oncology Search Engine (PRIMROSE) for cancer patients that retrieves scientific articles and clinical trials based on a patient's condition, genetic profile, age, and gender. Our search engine utilizes Elasticsearch indexes for information storage and retrieval, and we developed a knowledge graph for query expansion in order to improve recall. Additionally, we experimented with machine learning and learning-to-rank components to the search engine and compared the results of the two approaches. Finally, we developed a front-facing ReactJS website and a REST API for connecting with our search engine. The development of this front-facing website allows for easy access to our system by healthcare providers.
Types de publication
Journal Article
Langues
eng
Pagination
579-588Informations de copyright
©2020 AMIA - All rights reserved.
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