A Population-Based Study of Simvastatin Drug-Drug Interactions in Cardiovascular Disease Patients.
Journal
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
ISSN: 2153-4063
Titre abrégé: AMIA Jt Summits Transl Sci Proc
Pays: United States
ID NLM: 101539486
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
2
6
2020
Statut:
epublish
Résumé
Simvastatin is a commonly used medication for lipid management and cardiovascular disease, however, the risk of adverse events (AEs) with its use increases via drug-drug interaction (DDI) exposures. Patients were extracted if initially diagnosed with cardiovascular disease and newly initiated simvastatin therapy. The cohort was divided into a DDI-exposed group and a non-DDI exposed group. The DDI-exposed group was further divided into gemfibrozil, clarithromycin, and erythromycin exposure groups. The outcome was defined as a composite of predefined AEs. Our results show that the simvastatin-DDI group had a higher illness burden with longer simvastatin exposure time and more medical care follow-up compared with the simvastatin-non-DDI exposed group. AEs occurred more frequently in subjects exposed to interacting drugs with a higher risk for clarithromycin and erythromycin exposed subjects than for gemfibrozil subjects.
Types de publication
Journal Article
Langues
eng
Pagination
664-673Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL143390
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002494
Pays : United States
Informations de copyright
©2020 AMIA - All rights reserved.
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